Literature DB >> 27346868

The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study.

Sultan Pehlivan1, Murat Serdar Gurses2, Mustafa Numan Ural2, Sumeyya Akyol3, Filiz Eren4, Nursel Turkmen Inanir2, Mehmet Akif Gulec5, Bulent Eren4, Recep Fedakar2, Kadir Demircan3, Omer Akyol6.   

Abstract

OBJECTIVE: To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI.
METHODS: Thirty autopsied individuals were allocated into 2 groups, namely, a study group of individuals who died of myocardial infarction (n = 20), and a control group who died of trauma (n = 10). We performed standard immunohistochemical staining on myocardial tissue specimens, studying anti-ADAMTS1, anti-versican, and anti-versican C terminal peptide sequence (DPEAAE) fragments.
RESULTS: Strong, diffuse staining was observed throughout myocardial tissue for ADAMTS1 in the 2 groups. However, in the study group, we observed no expression for ADAMTS1 around fibrotic areas but detected slight staining in coagulative and necrotic zones.
CONCLUSION: Similar localizations of ADAMTS and fragmented versican in human heart tissue indicate that versican presumably is cleaved by ADAMTS1. Hence, ADAMTS1 can be regarded as a new marker for postmortem differential diagnosis of MI. © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  ADAMTS1; diagnosis; fragmented versican; myocardial infarction; postmortem; versican

Mesh：

Substances：

Year:  2016        PMID： 27346868      PMCID： PMC4985771          DOI： 10.1093/labmed/lmw022

Source DB:  PubMed          Journal:  Lab Med        ISSN： 0007-5027


  24 in total

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