| Literature DB >> 27345795 |
Francisco Zurita1, Teresa Galera1, Cristina González-Páramos1, Ana Moreno-Izquierdo2, Peter Schneiderat3, Mario F Fraga4, Agustin F Fernández5, Rafael Garesse1, M Esther Gallardo6.
Abstract
Human iPSC line PG64SV.2 was generated from fibroblasts of a patient with a defect of intergenomic communication. This patient harbored a homozygous mutation (c.2243G>C; p.Trp748Ser) in the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma gene (POLG). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non integrative methodology that involves the use of Sendai virus.Entities:
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Year: 2015 PMID： 27345795 DOI： 10.1016/j.scr.2015.12.016
Source DB: PubMed Journal: Stem Cell Res ISSN： 1873-5061 Impact factor: 2.020