Sanaz Kaviani1, Navid Zeraatkar1, Salar Sajedi1, Afshin Akbarzadeh1, Nahid Gorjizadeh2, Mohammad Hossein Farahani1, Behnoosh Teimourian1, Pardis Ghafarian3, Hamid Sabet4, Mohammad Reza Ay5. 1. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran. 2. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. 3. Chronic Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; PET/CT and Cyclotron Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Massachusetts General Hospital, Harvard Medical School, Boston, USA. 5. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mohammadreza_ay@tums.ac.ir.
Abstract
PURPOSE: We developed a high performance portable gamma camera platform dedicated to identification of sentinel lymph nodes (SLNs) and radio-guided surgery for cancer patients. In this work, we present the performance characteristics of SURGEOSIGHT-I, the first version of this platform that can intra-operatively provide high-resolution images of the surveyed areas. METHODS: At the heart of this camera, there is a 43×43 array of pixelated sodium-activated cesium iodide (CsI(Na)) scintillation crystal with 1×1mm(2) pixel size and 5mm thickness coupled to a Hamamatsu H8500 flat-panel multi-anode (64 channels) photomultiplier tube. The probe is equipped with a hexagonal parallel-hole lead collimator with 1.2mm holes. The detector, collimator, and the associated front-end electronics are encapsulated in a common housing referred to as head. RESULTS: Our results show a count rate of ∼41kcps for 20% count loss. The extrinsic energy resolution was measured as 20.6% at 140keV. The spatial resolution and the sensitivity of the system on the collimator surface was measured as 2.2mm and 142cps/MBq, respectively. In addition, the integral and differential uniformity, after uniformity correction, in useful field-of-view (UFOV) were measured 4.5% and 4.6%, respectively. CONCLUSIONS: This system can be used for a number of clinical applications including SLN biopsy and radiopharmaceutical-guided surgery.
PURPOSE: We developed a high performance portable gamma camera platform dedicated to identification of sentinel lymph nodes (SLNs) and radio-guided surgery for cancerpatients. In this work, we present the performance characteristics of SURGEOSIGHT-I, the first version of this platform that can intra-operatively provide high-resolution images of the surveyed areas. METHODS: At the heart of this camera, there is a 43×43 array of pixelated sodium-activated cesium iodide (CsI(Na)) scintillation crystal with 1×1mm(2) pixel size and 5mm thickness coupled to a Hamamatsu H8500 flat-panel multi-anode (64 channels) photomultiplier tube. The probe is equipped with a hexagonal parallel-hole lead collimator with 1.2mm holes. The detector, collimator, and the associated front-end electronics are encapsulated in a common housing referred to as head. RESULTS: Our results show a count rate of ∼41kcps for 20% count loss. The extrinsic energy resolution was measured as 20.6% at 140keV. The spatial resolution and the sensitivity of the system on the collimator surface was measured as 2.2mm and 142cps/MBq, respectively. In addition, the integral and differential uniformity, after uniformity correction, in useful field-of-view (UFOV) were measured 4.5% and 4.6%, respectively. CONCLUSIONS: This system can be used for a number of clinical applications including SLN biopsy and radiopharmaceutical-guided surgery.