Nanna Aue Sobol1, Kristine Hoffmann2, Kristian Steen Frederiksen2, Asmus Vogel3, Karsten Vestergaard4, Hans Brændgaard5, Hanne Gottrup5, Annette Lolk6, Lene Wermuth6, Søren Jakobsen7, Lars Laugesen8, Robert Gergelyffy8, Peter Høgh9, Eva Bjerregaard10, Volkert Siersma11, Birgitte Bo Andersen2, Peter Johannsen2, Gunhild Waldemar2, Steen Gregers Hasselbalch2, Nina Beyer12. 1. Musculoskeletal Rehabilitation Research Unit and Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. 2. Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 3. Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Psychology, University of Copenhagen, Copenhagen, Denmark. 4. Dementia Clinic, Aalborg University Hospital, Aalborg, Denmark. 5. Dementia Clinic, Aarhus University Hospital, Aarhus N, Denmark. 6. Dementia Clinic, Odense University Hospital, Odense, Denmark. 7. Department of Geriatrics, Odense University Hospital, Svendborg Hospital, Svendborg, Denmark. 8. Department of Geriatrics, Slagelse Hospital, Slagelse, Denmark. 9. Zeland University Hospital, Department of Neurology, Regional Dementia Research Centre, Roskilde, Denmark. 10. Memory Clinic, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. 11. Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 12. Musculoskeletal Rehabilitation Research Unit and Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address: ninabeyer.privat@gmail.com.
Abstract
INTRODUCTION: Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease. METHODS: The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensityaerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy. RESULTS: Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance. DISCUSSION: Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.
RCT Entities:
INTRODUCTION: Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease. METHODS: The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy. RESULTS: Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance. DISCUSSION: Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.
Authors: Lisa A van der Kleij; Esben T Petersen; Hartwig R Siebner; Jeroen Hendrikse; Kristian S Frederiksen; Nanna A Sobol; Steen G Hasselbalch; Ellen Garde Journal: Neuroimage Clin Date: 2018-09-04 Impact factor: 4.881