Kenichiro Harada1, Koji Matsuo2, Mami Nakashima3, Teruyuki Hobara4, Naoko Higuchi1, Fumihiro Higuchi1, Masayuki Nakano5, Koji Otsuki6, Tomohiko Shibata7, Toshio Watanuki1, Toshio Matsubara8, Yusuke Fujita9, Keigo Shimoji10, Hirotaka Yamagata1, Yoshifumi Watanabe1. 1. Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan. 2. Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan. Electronic address: kmatsuo@yamaguchi-u.ac.jp. 3. Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; Nagato-ichinomiya Hospital, Shimonoseki, Yamaguchi, Japan. 4. Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; Department of Psychiatry, Yamaguchi Grand Medical Center, Hofu, Yamaguchi, Japan. 5. Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; Katakura Hospital, Ube, Yamaguchi, Japan. 6. Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; Konan Hospital, Matsue, Shimane, Japan. 7. Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; Shinwaen Hospital, Onoda, Yamaguchi, Japan. 8. Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; Health Administration Center, Yamaguchi University Organization for University Education, Yamaguchi, Yamaguchi, Japan. 9. Department of Biomolecular Engineering Applied Molecular Bioscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan. 10. Department of Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
Abstract
BACKGROUND: Depression in old age is an increasing contributor to poor health and accompanying health care costs. Although there is an abundance of literature on later-life depression (LLD), the neural correlates have not been clarified. The aim of this study was to determine whether patients with LLD show abnormal gray matter volume (GMV) and white matter integrity by using multiple image analysis methods. METHODS: The study included 45 patients with LLD and 61 healthy participants who were matched for age, sex, years of education, and vascular risk factors. GMV was examined using voxel-based morphometry, while the white matter integrity was determined by tract-based spatial statistics and tract-specific analysis, which were obtained from high-resolution magnetic resonance images. RESULTS: Patients with LLD showed significantly less GMV in the orbitofrontal cortex, anterior cingulate, insula, amygdala, and temporal regions, as well as higher fractional anisotropy in the uncinate fasciculus, compared with healthy participants. Patients with LLD who had reduced orbitofrontal and insular GMV had more severe clinical variables. The reduced orbitofrontal GMV was associated with higher fractional anisotropy in the uncinate fasciculus. LIMITATION: The effects of medication should also be considered when interpreting the results of this study. CONCLUSION: Our results suggest that regional GMV is linked to white matter integrity of the uncinate fasciculus in the orbitomedial prefrontal limbic network, and the disruption of this network may be involved in the pathophysiology of LLD.
BACKGROUND:Depression in old age is an increasing contributor to poor health and accompanying health care costs. Although there is an abundance of literature on later-life depression (LLD), the neural correlates have not been clarified. The aim of this study was to determine whether patients with LLD show abnormal gray matter volume (GMV) and white matter integrity by using multiple image analysis methods. METHODS: The study included 45 patients with LLD and 61 healthy participants who were matched for age, sex, years of education, and vascular risk factors. GMV was examined using voxel-based morphometry, while the white matter integrity was determined by tract-based spatial statistics and tract-specific analysis, which were obtained from high-resolution magnetic resonance images. RESULTS:Patients with LLD showed significantly less GMV in the orbitofrontal cortex, anterior cingulate, insula, amygdala, and temporal regions, as well as higher fractional anisotropy in the uncinate fasciculus, compared with healthy participants. Patients with LLD who had reduced orbitofrontal and insular GMV had more severe clinical variables. The reduced orbitofrontal GMV was associated with higher fractional anisotropy in the uncinate fasciculus. LIMITATION: The effects of medication should also be considered when interpreting the results of this study. CONCLUSION: Our results suggest that regional GMV is linked to white matter integrity of the uncinate fasciculus in the orbitomedial prefrontal limbic network, and the disruption of this network may be involved in the pathophysiology of LLD.
Authors: Paul J Thomas; Srinivas Panchamukhi; Joshua Nathan; Jennifer Francis; Scott Langenecker; Stephanie Gorka; Alex Leow; Heide Klumpp; K Luan Phan; Olusola A Ajilore Journal: Psychiatry Res Neuroimaging Date: 2020-03-05 Impact factor: 2.376
Authors: Benoit H Mulsant; Aristotle N Voineskos; Neda Rashidi-Ranjbar; Tarek K Rajji; Sanjeev Kumar; Nathan Herrmann; Linda Mah; Alastair J Flint; Corinne E Fischer; Meryl A Butters; Bruce G Pollock; Erin W Dickie; John A E Anderson Journal: Neuropsychopharmacology Date: 2020-05-18 Impact factor: 7.853
Authors: Howard J Aizenstein; Andrius Baskys; Maura Boldrini; Meryl A Butters; Breno S Diniz; Manoj Kumar Jaiswal; Kurt A Jellinger; Lev S Kruglov; Ivan A Meshandin; Milija D Mijajlovic; Guenter Niklewski; Sarah Pospos; Keerthy Raju; Kneginja Richter; David C Steffens; Warren D Taylor; Oren Tene Journal: BMC Med Date: 2016-11-03 Impact factor: 8.775