| Literature DB >> 27344207 |
Julien P N Papillon1, Meihui Pan2, Margaret E Brousseau3, Mark A Gilchrist3, Changgang Lou4, Alok K Singh4, Todd Stawicki3, James E Thompson3.
Abstract
We designed and prepared synthetic phospholipids that generate lyso-phosphatidylcholine products with a unique mass for convenient detection by LC-MS in complex biological matrices. We demonstrated that compound 4, formulated either as a Triton X-100 emulsion or incorporated in synthetic HDL particles can serve as a substrate for plasma EL with useful specificity.Entities:
Keywords: Endothelial lipase; HPLC–MS/MS; Lipid analysis; Lipid mass spectrometry; Plasma assay; Synthetic phospholipids; Tandem mass spectrometry
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Year: 2016 PMID： 27344207 DOI： 10.1016/j.bmcl.2016.06.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823