Roya Kelishadi1, Fahimeh Jamshidi1, Mostafa Qorbani2, Mohammad Esmaeil Motlagh3, Ramin Heshmat4, Gelayol Ardalan1, Silva Hovsepian5. 1. Isfahan University of Medical Sciences, Research Institute for Primordial Prevention of Non-communicable Disease, Child Growth and Development Research Center, Isfahan, Iran. 2. Alborz University of Medical Sciences, Department of Community Medicine, Karaj, Iran; Tehran University of Medical Sciences, Endocrinology and Metabolism Population Sciences Institute, Chronic Diseases Research Center, Tehran, Iran. 3. Ahvaz Jundishapur University of Medical Sciences, Faculty of Medicine, Department of Pediatrics, Ahvaz, Iran. 4. Tehran University of Medical Sciences, Endocrinology and Metabolism Population Sciences Institute, Chronic Diseases Research Center, Tehran, Iran. 5. Isfahan University of Medical Sciences, Research Institute for Primordial Prevention of Non-communicable Disease, Child Growth and Development Research Center, Isfahan, Iran. Electronic address: silvahovsepsecret@gmail.com.
Abstract
OBJECTIVE: This study aims to investigate the role of metabolic syndrome (MetS) and the hypertriglyceridemic-waist (HW) phenotype in determining cardiometabolic risk factors and elevated liver enzymes in a national sample of Iranian pediatric population. METHOD: This nationwide study was conducted in the framework of the third survey of a surveillance program. Students, aged 10-18 years, were recruited from 27 provinces in Iran. The prevalence of cardiometabolic risk factors was compared in students with and without HW and MetS. The association of HW with different cardiometabolic risk factors was determined. RESULTS: The mean age of studied population was 14.73±2.41 years. Prevalence of HW and MetS was 3.3% and 4%, respectively. Sixty-nine (71.1%) participants with HW had MetS. The prevalence of obesity, elevated systolic blood pressure, hypercholesterolemia, and elevated alanine aminotransaminase (ALT) was significantly higher in subjects with HW phenotype and MetS than in their peers (p<0.05). A significant association was observed between HW and elevated levels of cholesterol and ALT, as well as between obesity and low HDL-C (p<0.05). CONCLUSIONS: The current findings serve as complementary evidence to previous studies, which have been mainly conducted among adults, suggesting that the HW phenotype is associated with cardiometabolic risk factors, especially with elevated cholesterol and ALT. The authors propose that, in primary care settings and in large epidemiological studies, the measurement of all MetS components can be replaced by studying HW as a screening tool for identifying children at high risk for cardiometabolic disorders.
OBJECTIVE: This study aims to investigate the role of metabolic syndrome (MetS) and the hypertriglyceridemic-waist (HW) phenotype in determining cardiometabolic risk factors and elevated liver enzymes in a national sample of Iranian pediatric population. METHOD: This nationwide study was conducted in the framework of the third survey of a surveillance program. Students, aged 10-18 years, were recruited from 27 provinces in Iran. The prevalence of cardiometabolic risk factors was compared in students with and without HW and MetS. The association of HW with different cardiometabolic risk factors was determined. RESULTS: The mean age of studied population was 14.73±2.41 years. Prevalence of HW and MetS was 3.3% and 4%, respectively. Sixty-nine (71.1%) participants with HW had MetS. The prevalence of obesity, elevated systolic blood pressure, hypercholesterolemia, and elevated alanine aminotransaminase (ALT) was significantly higher in subjects with HW phenotype and MetS than in their peers (p<0.05). A significant association was observed between HW and elevated levels of cholesterol and ALT, as well as between obesity and low HDL-C (p<0.05). CONCLUSIONS: The current findings serve as complementary evidence to previous studies, which have been mainly conducted among adults, suggesting that the HW phenotype is associated with cardiometabolic risk factors, especially with elevated cholesterol and ALT. The authors propose that, in primary care settings and in large epidemiological studies, the measurement of all MetS components can be replaced by studying HW as a screening tool for identifying children at high risk for cardiometabolic disorders.
Keywords:
Children and adolescent; Cintura hipertrigliceridêmica; Crianças e adolescentes; Hypertriglyceridemic waist; Lipid profile; Liver function test; Metabolic syndrome; Perfil lipídico; Síndrome metabólica; Teste da função hepática
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