Literature DB >> 2734313

Quantifying the infectivity of human immunodeficiency virus.

S P Layne1, J L Spouge, M Dembo.   

Abstract

We have developed a mathematical model that quantifies lymphocyte infection by human immunodeficiency virus (HIV) and lymphocyte protection by blocking agents such as soluble CD4. We use this model to suggest standardized parameters for quantifying viral infectivity and to suggest techniques for calculating these parameters from well-mixed infectivity assays. We discuss the implications of the model for our understanding of the infectious process and virulence of HIV in vivo.

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Year:  1989        PMID： 2734313      PMCID： PMC287327          DOI： 10.1073/pnas.86.12.4644

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  28 in total

1.  Evidence that T cell activation is required for HIV-1 entry in CD4+ lymphocytes.

Authors:  S D Gowda; B S Stein; N Mohagheghpour; C J Benike; E G Engleman
Journal:  J Immunol       Date:  1989-02-01       Impact factor: 5.422

2.  Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein.

Authors:  J D Lifson; M B Feinberg; G R Reyes; L Rabin; B Banapour; S Chakrabarti; B Moss; F Wong-Staal; K S Steimer; E G Engleman
Journal:  Nature       Date:  1986 Oct 23-29       Impact factor: 49.962

3.  Physics of chemoreception.

Authors:  H C Berg; E M Purcell
Journal:  Biophys J       Date:  1977-11       Impact factor: 4.033

4.  Effect of heat and fresh human serum on the infectivity of human T-cell lymphotropic virus type III evaluated with new bioassay systems.

Authors:  S Harada; H Yoshiyama; N Yamamoto
Journal:  J Clin Microbiol       Date:  1985-12       Impact factor: 5.948

5.  Fusion of influenza virus with cardiolipin liposomes at low pH: mass action analysis of kinetics and extent.

Authors:  S Nir; T Stegmann; J Wilschut
Journal:  Biochemistry       Date:  1986-01-14       Impact factor: 3.162

6.  Lipoprotein-associated oncornavirus-inactivating factor in the genus Mus: effects on murine leukemia viruses of laboratory and exotic mice.

Authors:  P L Nara; N M Dunlop; W G Robey; R Callahan; P J Fischinger
Journal:  Cancer Res       Date:  1987-02-01       Impact factor: 12.701

7.  pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane.

Authors:  B S Stein; S D Gowda; J D Lifson; R C Penhallow; K G Bensch; E G Engleman
Journal:  Cell       Date:  1987-06-05       Impact factor: 41.582

8.  Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen.

Authors:  J S McDougal; A Mawle; S P Cort; J K Nicholson; G D Cross; J A Scheppler-Campbell; D Hicks; J Sligh
Journal:  J Immunol       Date:  1985-11       Impact factor: 5.422

9.  Shedding and interspecies type sero-reactivity of the envelope glycopolypeptide gp120 of the human immunodeficiency virus.

Authors:  J Schneider; O Kaaden; T D Copeland; S Oroszlan; G Hunsmann
Journal:  J Gen Virol       Date:  1986-11       Impact factor: 3.891

10.  Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins.

Authors:  H R Gelderblom; E H Hausmann; M Ozel; G Pauli; M A Koch
Journal:  Virology       Date:  1987-01       Impact factor: 3.616
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  19 in total

1.  A practical method for simultaneously determining the effective burst sizes and cycle times of viruses.

Authors:  J L Spouge; S P Layne
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-08       Impact factor: 11.205

2.  Statistical analysis of sparse infection data and its implications for retroviral treatment trials in primates.

Authors:  J L Spouge
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

3.  Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia.

Authors:  Daniel B Reeves; Christopher W Peterson; Hans-Peter Kiem; Joshua T Schiffer
Journal:  J Virol       Date:  2017-06-09       Impact factor: 5.103

4.  Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization.

Authors:  J A McKeating; A McKnight; J P Moore
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

5.  Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates.

Authors:  J P Moore; J A McKeating; Y X Huang; A Ashkenazi; D D Ho
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

6.  Similar replication capacities of primary human immunodeficiency virus type 1 isolates derived from a wide range of clinical sources.

Authors:  W Lu; J M Andrieu
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

7.  Evolutionary game theoretic strategy for optimal drug delivery to influence selection pressure in treatment of HIV-1.

Authors:  Yu Wu; Mingjun Zhang; Jing Wu; Xiaopeng Zhao; Lijin Xia
Journal:  J Math Biol       Date:  2011-04-19       Impact factor: 2.259

8.  Analytic results for quantifying HIV infectivity.

Authors:  J L Spouge; S P Layne; M Dembo
Journal:  Bull Math Biol       Date:  1989       Impact factor: 1.758

9.  Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.

Authors:  P J Klasse; J P Moore
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

10.  Viral multiplicity of attachment and its implications for human immunodeficiency virus therapies.

Authors:  J L Spouge
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103
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