Wieying Kuo1, Eleni-Rosalina Andrinopoulou2, Adria Perez-Rovira3, Hadiye Ozturk4, Marleen de Bruijne5, Harm A W M Tiddens6. 1. Dept. of Pediatric Pulmonology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands; Dept. of Radiology, Erasmus MC, Rotterdam, The Netherlands. 2. Dept. of Biostatistics, Erasmus MC, Rotterdam, The Netherlands. 3. Dept. of Pediatric Pulmonology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands; Biomedical Imaging Group Rotterdam, Dept. of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands. 4. Dept. of Pediatric Pulmonology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. 5. Biomedical Imaging Group Rotterdam, Dept. of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands; Department of Computer Science, University of Copenhagen, Copenhagen, Denmark. 6. Dept. of Pediatric Pulmonology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands; Dept. of Radiology, Erasmus MC, Rotterdam, The Netherlands. Electronic address: h.tiddens@erasmusmc.nl.
Abstract
Background: CF-CT and PRAGMA-CF are commonly used scoring methods to quantify the severity of bronchiectasis (BE) and airway wall thickening (AWT) on chest CTs of children with cystic fibrosis (CF). We aimed to validate CF-CT and PRAGMA-CF sub-scores for BE and AWT against quantitative airway–artery (AA) dimensions. Methods: This is a retrospective study with 23 spirometer guided inspiratory chest CTs (11 CF, 12 controls; age range 6 to 16 years old) included. AA-, and AWTA-ratios of all visible AA pairs were computed by dividing diameters of the outer airway and wall (outer-inner airway) by the accompanying artery diameter, respectively. BE, AWT and total airway disease (TAD) were scored using CF-CT (% max score) and PRAGMA-CF (% extent). Correlations were computed using Spearman rank. Akaike information criterion (AIC) from the mixed-effects models were used to investigate whether CF-CT or PRAGMA-CF was a better predictor for AA-, and AWTA-ratios (lower AIC equals a better fitted model). Results: 4861 AA pairs were measured in total. Correlations between CF-CT and PRAGMA-CF: BE (r = 0.93, P < 0.001); AWT (r = 0.62, P < 0.001); TAD (r = 0.88, P < 0.001). PRAGMA-CF TAD sub-score had lowest AIC in the mixed-model predicting AA-ratio. CF-CT AWT and PRAGMA-CF TAD sub-score had equal low AIC in the mixed-model predicting AWTA-ratio. Conclusion: PRAGMA-CF TAD sub-score was more precise predicting BE. CF-CT AWT and PRAGMA-CF TAD sub-scores predicted AWT equally well. CF-CT and PRAGMA-CF were both sensitive methods to score BE and AWT in children with CF lung disease, with PRAGMA-CT TAD sub-score being most accurate in predicting AA dimensions.
Background: CF-CT and PRAGMA-CF are commonly used scoring methods to quantify the severity of bronchiectasis (BE) and airway wall thickening (AWT) on chest CTs of children with cystic fibrosis (CF). We aimed to validate CF-CT and PRAGMA-CF sub-scores for BE and AWT against quantitative airway–artery (AA) dimensions. Methods: This is a retrospective study with 23 spirometer guided inspiratory chest CTs (11 CF, 12 controls; age range 6 to 16 years old) included. AA-, and AWTA-ratios of all visible AA pairs were computed by dividing diameters of the outer airway and wall (outer-inner airway) by the accompanying artery diameter, respectively. BE, AWT and total airway disease (TAD) were scored using CF-CT (% max score) and PRAGMA-CF (% extent). Correlations were computed using Spearman rank. Akaike information criterion (AIC) from the mixed-effects models were used to investigate whether CF-CT or PRAGMA-CF was a better predictor for AA-, and AWTA-ratios (lower AIC equals a better fitted model). Results: 4861 AA pairs were measured in total. Correlations between CF-CT and PRAGMA-CF: BE (r = 0.93, P < 0.001); AWT (r = 0.62, P < 0.001); TAD (r = 0.88, P < 0.001). PRAGMA-CF TAD sub-score had lowest AIC in the mixed-model predicting AA-ratio. CF-CT AWT and PRAGMA-CF TAD sub-score had equal low AIC in the mixed-model predicting AWTA-ratio. Conclusion: PRAGMA-CF TAD sub-score was more precise predicting BE. CF-CT AWT and PRAGMA-CF TAD sub-scores predicted AWT equally well. CF-CT and PRAGMA-CF were both sensitive methods to score BE and AWT in children with CF lung disease, with PRAGMA-CT TAD sub-score being most accurate in predicting AA dimensions.
Authors: Philip Konietzke; Oliver Weinheimer; Mark O Wielpütz; Dasha Savage; Tiglath Ziyeh; Christin Tu; Beverly Newman; Craig J Galbán; Marcus A Mall; Hans-Ulrich Kauczor; Terry E Robinson Journal: PLoS One Date: 2018-04-09 Impact factor: 3.240
Authors: Merel C J Oudraad; Wieying Kuo; Tim Rosenow; Eleni-Rosalina Andrinopoulou; Stephen M Stick; Harm A W M Tiddens Journal: Pediatr Pulmonol Date: 2020-03-02