Literature DB >> 2734294

Two peptides related to platelet-derived growth factor are present in human wound fluid.

J Matsuoka1, G R Grotendorst.   

Abstract

Platelet-derived growth factor (PDGF) has been suggested to play an important role in wound healing. In this study wound fluid collected from patients after radical mastectomy was analyzed for PDGF-related factors. Analysis revealed the presence of two PDGF-related peptides of 16-17 kDa and 34-36 kDa. These PDGF-related peptides were purified by using anti-PDGF immunoaffinity techniques and found to possess both chemotactic and mitogenic activities for NIH 3T3 cells in vitro. Surprisingly, we could not detect authentic native PDGF (30 kDa) or PDGF A or B chain in any of the wound-fluid samples examined. These results indicate that PDGF-related peptides are present in normal human wound fluid, whereas PDGF A- and B-chain peptides are absent or only present in trace amounts relative to the total PDGF-related biological activity.

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Year:  1989        PMID： 2734294      PMCID： PMC287280          DOI： 10.1073/pnas.86.12.4416

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

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  17 in total

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Journal:  J Clin Invest       Date:  1995-01       Impact factor: 14.808

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Review 5.  Role of angiogenesis in endodontics: contributions of stem cells and proangiogenic and antiangiogenic factors to dental pulp regeneration.

Authors:  Mohammad Ali Saghiri; Armen Asatourian; Christine M Sorenson; Nader Sheibani
Journal:  J Endod       Date:  2015-01-31       Impact factor: 4.171

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Authors:  H N Antoniades; T Galanopoulos; J Neville-Golden; C P Kiritsy; S E Lynch
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

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