Angiogenesis in Colorectal Cancer: Antibodies.

Angiogenesis is critical to tumor cell growth. Vascular endothelial growth factor and its receptors play key roles in this pathway and are targets for cancer drug therapy. Blockade of the angiogenesis pathway has shown efficacy and led to improvements in survival in several tumor types. This chapter focuses on the intraveneous antiangiogenic agents approved in metastatic colorectal cancer and their role in the treatment of this disease.