BACKGROUND: Many neuroimaging parameters have demonstrated utility as biomarkers in preclinical AD, including resting-state functional connectivity in the default mode network. However, neuroimaging is not a practical, cost effective screening instrument. OBJECTIVE: Here we investigate the relationship between performance on a cognitive-motor integration assessment and alterations in resting-state functional connectivity in an at-risk population. METHODS: Three groups of ten adults (young: mean age = 26.6 ± 2.7, low AD risk: mean age = 58.7 ± 5.6, and high AD risk: mean age = 58.5 ± 6.9) performed a simple cognitive-motor integration task using a dual-touchscreen laptop and also underwent functional magnetic resonance imaging at rest. RESULTS: We found poorer cognitive-motor integration performance in high AD risk participants, as well as an association with lower resting-state functional connectivity in this group. CONCLUSION: These findings provide novel insight into underlying AD-related brain alterations associated with a behavioral assessment that can be easily administered clinically.
BACKGROUND: Many neuroimaging parameters have demonstrated utility as biomarkers in preclinical AD, including resting-state functional connectivity in the default mode network. However, neuroimaging is not a practical, cost effective screening instrument. OBJECTIVE: Here we investigate the relationship between performance on a cognitive-motor integration assessment and alterations in resting-state functional connectivity in an at-risk population. METHODS: Three groups of ten adults (young: mean age = 26.6 ± 2.7, low AD risk: mean age = 58.7 ± 5.6, and high AD risk: mean age = 58.5 ± 6.9) performed a simple cognitive-motor integration task using a dual-touchscreen laptop and also underwent functional magnetic resonance imaging at rest. RESULTS: We found poorer cognitive-motor integration performance in high AD risk participants, as well as an association with lower resting-state functional connectivity in this group. CONCLUSION: These findings provide novel insight into underlying AD-related brain alterations associated with a behavioral assessment that can be easily administered clinically.
Entities:
Keywords:
Aging; ApoE4; dementia; functional magnetic resonance imaging; geriatric assessment; population at risk; psychomotor performance
Authors: Alexandra G Mitchell; Stephanie Rossit; Suvankar Pal; Michael Hornberger; Annie Warman; Elise Kenning; Laura Williamson; Rebecca Shapland; Robert D McIntosh Journal: Cortex Date: 2022-01-31 Impact factor: 4.027
Authors: Kirsty Lu; Jennifer M Nicholas; Philip S J Weston; Julie C Stout; Alison M O'Regan; Sarah-Naomi James; Sarah M Buchanan; Christopher A Lane; Thomas D Parker; Sarah E Keuss; Ashvini Keshavan; Heidi Murray-Smith; David M Cash; Carole H Sudre; Ian B Malone; William Coath; Andrew Wong; Marcus Richards; Susie M D Henley; Nick C Fox; Jonathan M Schott; Sebastian J Crutch Journal: Brain Commun Date: 2021-01-25