T-W Chiu1,2, Y-J Liu2, H-C Chang3, Y-H Lee2, J-C Lee4,5, K Hsu6, C-W Wang1,7, J-M Yang5, H-H Hsu1,7, C-J Juan8,7. 1. From the Departments of Radiology (T.-W.C., C.-W.W., H.-H.H., C.-J.J.). 2. Department of Medicine (T.-W.C.), Taipei Medical University, Taipei, Taiwan. 3. Department of Diagnostic Radiology (H.-C.C.), The University of Hong Kong, Hong Kong. 4. Department of Otolaryngology-Head and Neck Surgery (J.-C.L.), Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. 5. Department of Biological Science and Technology (J.-C.L., J.-M.Y.), Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan. 6. Dentistry (K.H.), National Defense Medical Center, Taipei, Taiwan. 7. Department of Radiology (C.-W.W., H.-H.H., C.-J.J.), Tri-Service General Hospital, Taipei, Taiwan. 8. From the Departments of Radiology (T.-W.C., C.-W.W., H.-H.H., C.-J.J.) peterjuancj@yahoo.com.tw.
Abstract
BACKGROUND AND PURPOSE: Parotid glands secrete and empty saliva into the oral cavity rapidly after gustatory stimulation. However, the role of the temporal resolution of DWI in investigating parotid gland function remains uncertain. Our aim was to design a high-temporal-resolution echo-planar DWI pulse sequence and to evaluate the instantaneous MR perfusion responses of the parotid glands to gustatory stimulation. MATERIALS AND METHODS: This prospective study enrolled 21 healthy volunteers (M/F = 2:1; mean age, 45.2 ± 12.9 years). All participants underwent echo-planar DWI (total scan time, 304 seconds; temporal resolution, 4 s/scan) on a 1.5T MR imaging scanner. T2WI (b = 0 s/mm2) and DWI (b = 200 s/mm2) were qualitatively assessed. Signal intensity of the parotid glands on T2WI, DWI, and ADC was quantitatively analyzed. One-way ANOVA with post hoc group comparisons with Bonferroni correction was used for statistical analysis. P < .05 was statistically significant. RESULTS: Almost perfect interobserver agreement was achieved (κ ≥ 0.656). The parotid glands had magnetic susceptibility artifacts in 14.3% (3 of 21) of volunteers during swallowing on DWI but were free from perceptible artifacts at the baseline and at the end of scans on all images. Increased ADC and reduced signal intensity of the parotid glands on T2WI and DWI occurred immediately after oral administration of lemon juice. Maximal signal change of ADC (24.8% ± 10.8%) was significantly higher than that of T2WI (-10.1% ± 5.2%, P < .001). The recovery ratio of ADC (100.71% ± 42.34%) was also significantly higher than that of T2WI (22.36% ± 15.54%, P < .001). CONCLUSIONS: Instantaneous parotid perfusion responses to gustatory stimulation can be quantified by ADC by using high-temporal-resolution echo-planar DWI.
BACKGROUND AND PURPOSE: Parotid glands secrete and empty saliva into the oral cavity rapidly after gustatory stimulation. However, the role of the temporal resolution of DWI in investigating parotid gland function remains uncertain. Our aim was to design a high-temporal-resolution echo-planar DWI pulse sequence and to evaluate the instantaneous MR perfusion responses of the parotid glands to gustatory stimulation. MATERIALS AND METHODS: This prospective study enrolled 21 healthy volunteers (M/F = 2:1; mean age, 45.2 ± 12.9 years). All participants underwent echo-planar DWI (total scan time, 304 seconds; temporal resolution, 4 s/scan) on a 1.5T MR imaging scanner. T2WI (b = 0 s/mm2) and DWI (b = 200 s/mm2) were qualitatively assessed. Signal intensity of the parotid glands on T2WI, DWI, and ADC was quantitatively analyzed. One-way ANOVA with post hoc group comparisons with Bonferroni correction was used for statistical analysis. P < .05 was statistically significant. RESULTS: Almost perfect interobserver agreement was achieved (κ ≥ 0.656). The parotid glands had magnetic susceptibility artifacts in 14.3% (3 of 21) of volunteers during swallowing on DWI but were free from perceptible artifacts at the baseline and at the end of scans on all images. Increased ADC and reduced signal intensity of the parotid glands on T2WI and DWI occurred immediately after oral administration of lemon juice. Maximal signal change of ADC (24.8% ± 10.8%) was significantly higher than that of T2WI (-10.1% ± 5.2%, P < .001). The recovery ratio of ADC (100.71% ± 42.34%) was also significantly higher than that of T2WI (22.36% ± 15.54%, P < .001). CONCLUSIONS: Instantaneous parotid perfusion responses to gustatory stimulation can be quantified by ADC by using high-temporal-resolution echo-planar DWI.
Authors: Moti Freiman; Stephan D Voss; Robert V Mulkern; Jeannette M Perez-Rossello; Michael J Callahan; Simon K Warfield Journal: Med Phys Date: 2012-08 Impact factor: 4.071
Authors: C R Habermann; C Arndt; J Graessner; L Diestel; K U Petersen; F Reitmeier; J O Ussmueller; G Adam; M Jaehne Journal: AJNR Am J Neuroradiol Date: 2009-01-08 Impact factor: 3.825