| Literature DB >> 27339627 |
Paulette A Krishack1, Timothy J Sontag2, Godfrey S Getz1,2, Catherine A Reardon1,2.
Abstract
We previously showed that feeding a Western-type diet (WTD) to Ldlr(-/-) mice lacking serum amyloid A (SAA) (Saa(-/-) Ldlr(-/-) mice), the level of total blood monocytes was higher than in Ldlr(-/-) mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage-dendritic cell progenitor (MDP) cells were found in WTD-fed Saa(-/-) Ldlr(-/-) mice compared to Ldlr(-/-) mice and lower levels of GMP cells and CMP cells in Ldlr(-/-) mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice.Entities:
Keywords: Western-type diet; monocytes; monopoiesis; serum amyloid A; stem cells
Mesh:
Substances:
Year: 2016 PMID: 27339627 PMCID: PMC4992419 DOI: 10.1002/1873-3468.12269
Source DB: PubMed Journal: FEBS Lett ISSN: 0014-5793 Impact factor: 4.124