Literature DB >> 27339627

Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr(-/-) mice.

Paulette A Krishack1, Timothy J Sontag2, Godfrey S Getz1,2, Catherine A Reardon1,2.   

Abstract

We previously showed that feeding a Western-type diet (WTD) to Ldlr(-/-) mice lacking serum amyloid A (SAA) (Saa(-/-) Ldlr(-/-) mice), the level of total blood monocytes was higher than in Ldlr(-/-) mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage-dendritic cell progenitor (MDP) cells were found in WTD-fed Saa(-/-) Ldlr(-/-) mice compared to Ldlr(-/-) mice and lower levels of GMP cells and CMP cells in Ldlr(-/-) mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice.
© 2016 Federation of European Biochemical Societies.

Entities:  

Keywords:  Western-type diet; monocytes; monopoiesis; serum amyloid A; stem cells

Mesh:

Substances:

Year:  2016        PMID: 27339627      PMCID: PMC4992419          DOI: 10.1002/1873-3468.12269

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  31 in total

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  1 in total

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