| Literature DB >> 27339132 |
Lars Nyberg1, Nina Karalija2, Alireza Salami3, Micael Andersson4, Anders Wåhlin2, Neda Kaboovand3, Ylva Köhncke3, Jan Axelsson2, Anna Rieckmann2, Goran Papenberg3, Douglas D Garrett5, Katrine Riklund2, Martin Lövdén3, Ulman Lindenberger6, Lars Bäckman3.
Abstract
D1 and D2 dopamine receptors (D1DRs and D2DRs) may contribute differently to various aspects of memory and cognition. The D1DR system has been linked to functions supported by the prefrontal cortex. By contrast, the role of the D2DR system is less clear, although it has been hypothesized that D2DRs make a specific contribution to hippocampus-based cognitive functions. Here we present results from 181 healthy adults between 64 and 68 y of age who underwent comprehensive assessment of episodic memory, working memory, and processing speed, along with MRI and D2DR assessment with [(11)C]raclopride and PET. Caudate D2DR availability was positively associated with episodic memory but not with working memory or speed. Whole-brain analyses further revealed a relation between hippocampal D2DR availability and episodic memory. Hippocampal and caudate D2DR availability were interrelated, and functional MRI-based resting-state functional connectivity between the ventral caudate and medial temporal cortex increased as a function of caudate D2DR availability. Collectively, these findings indicate that D2DRs make a specific contribution to hippocampus-based cognition by influencing striatal and hippocampal regions, and their interactions.Entities:
Keywords: dopamine; hippocampus; memory
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Year: 2016 PMID： 27339132 PMCID： PMC4948341 DOI： 10.1073/pnas.1606309113
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205