Literature DB >> 27338593

Wearables, Smartphones and Novel Anticoagulants: We Will Treat More Atrial Fibrillation, but Will Patients Be Better Off?

Adam Cifu1, Vinay Prasad2,3,4.   

Abstract

The widespread adoption of medical practices without a firm evidence base is common and the current growing enthusiasm for atrial fibrillation screening offers a real-time example of this phenomenon. Although no randomized trials supporting the utility of screening for atrial fibrillation exist, proponents suggest that such screening should be considered. Atrial fibrillation is a common condition that is often asymptomatic. It is also a condition associated with serious morbidity, primarily resulting from stroke. We practice at a time in which the ability to detect atrial fibrillation is becoming easier and treatments are becoming less onerous. Screening for atrial fibrillation may be beneficial but there is also a reasonable likelihood that its harms will outweigh it benefits. In this article we make the case that adopting this practice prior to data from randomized controlled trial would be a mistake. If screening for atrial fibrillation is adopted without such a robust evidence base we may well later discover that this course of action was wrong.

Entities:  

Keywords:  anticoagulation; atrial fibrillation; medical decision making; medical reversal

Mesh:

Substances:

Year:  2016        PMID: 27338593      PMCID: PMC5071280          DOI: 10.1007/s11606-016-3761-8

Source DB:  PubMed          Journal:  J Gen Intern Med        ISSN: 0884-8734            Impact factor:   5.128


  11 in total

1.  A comparison of rate control and rhythm control in patients with atrial fibrillation.

Authors:  D G Wyse; A L Waldo; J P DiMarco; M J Domanski; Y Rosenberg; E B Schron; J C Kellen; H L Greene; M C Mickel; J E Dalquist; S D Corley
Journal:  N Engl J Med       Date:  2002-12-05       Impact factor: 91.245

2.  Asymptomatic Atrial Fibrillation: The Case for Screening to Prevent Stroke.

Authors:  S Ben Freedman; Nicole Lowres
Journal:  JAMA       Date:  2015-11-10       Impact factor: 56.272

3.  Improving stroke risk stratification using the CHADS2 and CHA2DS2-VASc risk scores in patients with paroxysmal atrial fibrillation by continuous arrhythmia burden monitoring.

Authors:  Giuseppe Boriani; Giovanni Luca Botto; Luigi Padeletti; Massimo Santini; Alessandro Capucci; Michele Gulizia; Renato Ricci; Mauro Biffi; Tiziana De Santo; Giorgio Corbucci; Gregory Y H Lip
Journal:  Stroke       Date:  2011-04-14       Impact factor: 7.914

4.  The diagnosis and treatment of pulmonary embolism: a metaphor for medicine in the evidence-based medicine era.

Authors:  Vinay Prasad; Jason Rho; Adam Cifu
Journal:  Arch Intern Med       Date:  2012-06-25

5.  A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke.

Authors:  J P Mohr; J L Thompson; R M Lazar; B Levin; R L Sacco; K L Furie; J P Kistler; G W Albers; L C Pettigrew; H P Adams; C M Jackson; P Pullicino
Journal:  N Engl J Med       Date:  2001-11-15       Impact factor: 91.245

6.  Apixaban versus warfarin in patients with atrial fibrillation.

Authors:  Christopher B Granger; John H Alexander; John J V McMurray; Renato D Lopes; Elaine M Hylek; Michael Hanna; Hussein R Al-Khalidi; Jack Ansell; Dan Atar; Alvaro Avezum; M Cecilia Bahit; Rafael Diaz; J Donald Easton; Justin A Ezekowitz; Greg Flaker; David Garcia; Margarida Geraldes; Bernard J Gersh; Sergey Golitsyn; Shinya Goto; Antonio G Hermosillo; Stefan H Hohnloser; John Horowitz; Puneet Mohan; Petr Jansky; Basil S Lewis; Jose Luis Lopez-Sendon; Prem Pais; Alexander Parkhomenko; Freek W A Verheugt; Jun Zhu; Lars Wallentin
Journal:  N Engl J Med       Date:  2011-08-27       Impact factor: 91.245

7.  Subclinical atrial fibrillation and the risk of stroke.

Authors:  Jeff S Healey; Stuart J Connolly; Michael R Gold; Carsten W Israel; Isabelle C Van Gelder; Alessandro Capucci; C P Lau; Eric Fain; Sean Yang; Christophe Bailleul; Carlos A Morillo; Mark Carlson; Ellison Themeles; Elizabeth S Kaufman; Stefan H Hohnloser
Journal:  N Engl J Med       Date:  2012-01-12       Impact factor: 91.245

8.  Atrial fibrillation in patients with cryptogenic stroke.

Authors:  David J Gladstone; Melanie Spring; Paul Dorian; Val Panzov; Kevin E Thorpe; Judith Hall; Haris Vaid; Martin O'Donnell; Andreas Laupacis; Robert Côté; Mukul Sharma; John A Blakely; Ashfaq Shuaib; Vladimir Hachinski; Shelagh B Coutts; Demetrios J Sahlas; Phil Teal; Samuel Yip; J David Spence; Brian Buck; Steve Verreault; Leanne K Casaubon; Andrew Penn; Daniel Selchen; Albert Jin; David Howse; Manu Mehdiratta; Karl Boyle; Richard Aviv; Moira K Kapral; Muhammad Mamdani
Journal:  N Engl J Med       Date:  2014-06-26       Impact factor: 91.245

9.  Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation.

Authors:  Gregory Y H Lip; Robby Nieuwlaat; Ron Pisters; Deirdre A Lane; Harry J G M Crijns
Journal:  Chest       Date:  2009-09-17       Impact factor: 9.410

10.  Dabigatran versus warfarin in patients with atrial fibrillation.

Authors:  Stuart J Connolly; Michael D Ezekowitz; Salim Yusuf; John Eikelboom; Jonas Oldgren; Amit Parekh; Janice Pogue; Paul A Reilly; Ellison Themeles; Jeanne Varrone; Susan Wang; Marco Alings; Denis Xavier; Jun Zhu; Rafael Diaz; Basil S Lewis; Harald Darius; Hans-Christoph Diener; Campbell D Joyner; Lars Wallentin
Journal:  N Engl J Med       Date:  2009-08-30       Impact factor: 91.245

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  1 in total

1.  CHAD is Dead: Pragmatic Utility of the CHA2DS2-VASc Score in Non-Valvular Atrial Fibrillation?

Authors:  T Raymond Foley; Mori J Krantz
Journal:  J Gen Intern Med       Date:  2018-01       Impact factor: 5.128

  1 in total

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