Literature DB >> 27338027

Feverish Quest for Ebola Immunotherapy: Straight or Cocktail?

Erica Ollmann Saphire1, M Javad Aman2.   

Abstract

The ebolavirus immunotherapeutics field has replaced previous perceptions of antibody inadequacy with a new abundance of monoclonals exhibiting post exposure efficacy. Now the questions are: what epitopes to target, what immunological mechanisms to seek, whether species-specific or broadly reactive antibodies are best, and whether a cocktail or monotherapy should be used.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27338027     DOI： 10.1016/j.tim.2016.05.008

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  15 in total

1.  Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability.

Authors:  Xuelian Zhao; Katie A Howell; Shihua He; Jennifer M Brannan; Anna Z Wec; Edgar Davidson; Hannah L Turner; Chi-I Chiang; Lin Lei; J Maximilian Fels; Hong Vu; Sergey Shulenin; Ashley N Turonis; Ana I Kuehne; Guodong Liu; Mi Ta; Yimeng Wang; Christopher Sundling; Yongli Xiao; Jennifer S Spence; Benjamin J Doranz; Frederick W Holtsberg; Andrew B Ward; Kartik Chandran; John M Dye; Xiangguo Qiu; Yuxing Li; M Javad Aman
Journal:  Cell       Date:  2017-05-18       Impact factor: 41.582

2.  Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates.

Authors:  Pavlo Gilchuk; Chad E Mire; Joan B Geisbert; Krystle N Agans; Daniel J Deer; Robert W Cross; James C Slaughter; Andrew I Flyak; Jeremy Mani; Michael H Pauly; Jesus Velasco; Kevin J Whaley; Larry Zeitlin; Thomas W Geisbert; James E Crowe
Journal:  J Infect Dis       Date:  2018-11-22       Impact factor: 5.226

3.  Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines.

Authors:  Linling He; Anshul Chaudhary; Xiaohe Lin; Cindy Sou; Tanwee Alkutkar; Sonu Kumar; Timothy Ngo; Ezra Kosviner; Gabriel Ozorowski; Robyn L Stanfield; Andrew B Ward; Ian A Wilson; Jiang Zhu
Journal:  Nat Commun       Date:  2021-05-11       Impact factor: 14.919

4.  Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization.

Authors:  Yimeng Wang; Katie A Howell; Jennifer Brannan; Krystle N Agans; Hannah L Turner; Ariel S Wirchnianski; Shweta Kailasan; Marnie Fusco; Andrey Galkin; Chi-I Chiang; Xuelian Zhao; Erica Ollmann Saphire; Kartik Chandran; Andrew B Ward; John M Dye; M Javad Aman; Thomas W Geisbert; Yuxing Li
Journal:  J Virol       Date:  2021-02-03       Impact factor: 6.549

5.  Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap.

Authors:  Philipp A Ilinykh; Rodrigo I Santos; Bronwyn M Gunn; Natalia A Kuzmina; Xiaoli Shen; Kai Huang; Pavlo Gilchuk; Andrew I Flyak; Patrick Younan; Galit Alter; James E Crowe; Alexander Bukreyev
Journal:  PLoS Pathog       Date:  2018-08-23       Impact factor: 6.823

6.  Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections.

Authors:  Zhengchen Su; Qing Chang; Aleksandra Drelich; Thomas Shelite; Barbara Judy; Yakun Liu; Jie Xiao; Changchen Zhou; Xi He; Yang Jin; Tais Saito; Shaojun Tang; Lynn Soong; Maki Wakamiya; Xiang Fang; Alexander Bukreyev; Thomas Ksiazek; William K Russell; Bin Gong
Journal:  PLoS Negl Trop Dis       Date:  2020-07-20

7.  Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.

Authors:  Pavlo Gilchuk; Natalia Kuzmina; Philipp A Ilinykh; Kai Huang; Bronwyn M Gunn; Aubrey Bryan; Edgar Davidson; Benjamin J Doranz; Hannah L Turner; Marnie L Fusco; Matthew S Bramble; Nicole A Hoff; Elad Binshtein; Nurgun Kose; Andrew I Flyak; Robin Flinko; Chiara Orlandi; Robert Carnahan; Erica H Parrish; Alexander M Sevy; Robin G Bombardi; Prashant K Singh; Patrick Mukadi; Jean Jacques Muyembe-Tamfum; Melanie D Ohi; Erica Ollmann Saphire; George K Lewis; Galit Alter; Andrew B Ward; Anne W Rimoin; Alexander Bukreyev; James E Crowe
Journal:  Immunity       Date:  2018-07-17       Impact factor: 31.745

8.  Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.

Authors:  Ivy Widjaja; Chunyan Wang; Rien van Haperen; Javier Gutiérrez-Álvarez; Brenda van Dieren; Nisreen M A Okba; V Stalin Raj; Wentao Li; Raul Fernandez-Delgado; Frank Grosveld; Frank J M van Kuppeveld; Bart L Haagmans; Luis Enjuanes; Dubravka Drabek; Berend-Jan Bosch
Journal:  Emerg Microbes Infect       Date:  2019       Impact factor: 7.163

9.  Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells.

Authors:  Aleksandra Drelich; Barbara Judy; Xi He; Qing Chang; Shangyi Yu; Xiang Li; Fanglin Lu; Maki Wakamiya; Vsevolod Popov; Jia Zhou; Thomas Ksiazek; Bin Gong
Journal:  Viruses       Date:  2018-10-16       Impact factor: 5.048

10.  Broad Neutralizing Activity Against Ebolaviruses Lacking the Mucin-Like Domain in Convalescent Plasma Specimens From Patients With Ebola Virus Disease.

Authors:  Joanna Luczkowiak; Fatima Lasala; Marta Mora-Rillo; Jose R Arribas; Rafael Delgado
Journal:  J Infect Dis       Date:  2018-11-22       Impact factor: 5.226
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