Literature DB >> 2733727

The effect of cilofungin (LY 121019) in combination with amphotericin B or flucytosine against Candida species.

A N Bulo, S F Bradley, C A Kauffman.   

Abstract

Cilofungin was combined with amphotericin B or flucytosine to determine if synergistic inhibition or killing occurred against 50 strains of various Candida species. Synergistic inhibition of growth occurred only once with amphotericin B and cilofungin and only 2 times with flucytosine and cilofungin. Synergistic killing occurred in 5 strains with the amphotericin B-cilofungin combination and in 7 strains with the flucytosine-cilofungin combination. Antagonism occurred frequently with both the amphotericin B-cilofungin and the flucytosine-cilofungin combinations.

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Year:  1989        PMID: 2733727     DOI: 10.1111/j.1439-0507.1989.tb02224.x

Source DB:  PubMed          Journal:  Mycoses        ISSN: 0933-7407            Impact factor:   4.377


  2 in total

1.  Synergy between cilofungin and amphotericin B in a murine model of candidiasis.

Authors:  L H Hanson; A M Perlman; K V Clemons; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1991-07       Impact factor: 5.191

2.  Treatment of murine invasive candidiasis with amphotericin B and cilofungin: evidence for enhanced activity with combination therapy.

Authors:  A M Sugar; L Z Goldani; M Picard
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

  2 in total

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