Literature DB >> 27335371

Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration.

Dikshya Bastakoty1, Pampee P Young2.   

Abstract

The Wnt/β-catenin pathway is an evolutionarily conserved set of signals with critical roles in embryonic and neonatal development across species. In mammals the pathway is quiescent in many organs. It is reactivated in response to injury and is reported to play complex and contrasting roles in promoting regeneration and fibrosis. We review the current understanding of the role of the Wnt/β-catenin pathway in injury of various mammalian organs and discuss the current advances and potential of Wnt inhibitory therapeutics toward promoting tissue regeneration and reducing fibrosis.-Bastakoty, D., Young, P. P. Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration. © FASEB.

Entities:  

Keywords:  fibrosis; inhibitor; repair; scar; wound healing

Mesh：

Substances：

Year:  2016        PMID： 27335371      PMCID： PMC5024694          DOI： 10.1096/fj.201600502R

Source DB:  PubMed          Journal:  FASEB J        ISSN： 0892-6638            Impact factor:   5.191


  175 in total

1.  Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.

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Journal:  Cell       Date:  2002-04-05       Impact factor: 41.582

2.  Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury.

Authors:  Dikshya Bastakoty; Sarika Saraswati; Justin Cates; Ethan Lee; Lillian B Nanney; Pampee P Young
Journal:  FASEB J       Date:  2015-08-12       Impact factor: 5.191

3.  Distinct Wnt signaling pathways have opposing roles in appendage regeneration.

Authors:  Cristi L Stoick-Cooper; Gilbert Weidinger; Kimberly J Riehle; Charlotte Hubbert; Michael B Major; Nelson Fausto; Randall T Moon
Journal:  Development       Date:  2006-12-21       Impact factor: 6.868

4.  A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.

Authors:  Andrew S Brack; Irina M Conboy; Michael J Conboy; Jeanne Shen; Thomas A Rando
Journal:  Cell Stem Cell       Date:  2008-01-10       Impact factor: 24.633

5.  The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling.

Authors:  S Dihlmann; A Siermann; M von Knebel Doeberitz
Journal:  Oncogene       Date:  2001-02-01       Impact factor: 9.867

6.  Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3.

Authors:  Angelos Oikonomopoulos; Konstantina-Ioanna Sereti; Frank Conyers; Michael Bauer; Annette Liao; Jian Guan; Dylan Crapps; Jung-Kyu Han; Hanhua Dong; Ahmad F Bayomy; Gabriel C Fine; Karen Westerman; Travis L Biechele; Randall T Moon; Thomas Force; Ronglih Liao
Journal:  Circ Res       Date:  2011-10-27       Impact factor: 17.367

7.  Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.

Authors:  Sharon Amit; Ada Hatzubai; Yaara Birman; Jens S Andersen; Etti Ben-Shushan; Matthias Mann; Yinon Ben-Neriah; Irit Alkalay
Journal:  Genes Dev       Date:  2002-05-01       Impact factor: 11.361

8.  Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis.

Authors:  Marco Chilosi; Venerino Poletti; Alberto Zamò; Maurizio Lestani; Licia Montagna; Paola Piccoli; Serena Pedron; Manuela Bertaso; Aldo Scarpa; Bruno Murer; Alessandra Cancellieri; Roberta Maestro; Gianpietro Semenzato; Claudio Doglioni
Journal:  Am J Pathol       Date:  2003-05       Impact factor: 4.307

9.  Macrophage Wnt7b is critical for kidney repair and regeneration.

Authors:  Shuei-Liong Lin; Bing Li; Sujata Rao; Eun-Jin Yeo; Thomas E Hudson; Brian T Nowlin; Huaying Pei; Lijun Chen; Jie J Zheng; Thomas J Carroll; Jeffrey W Pollard; Andrew P McMahon; Richard A Lang; Jeremy S Duffield
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-16       Impact factor: 11.205

10.  Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

Authors:  R Nusse; H E Varmus
Journal:  Cell       Date:  1982-11       Impact factor: 41.582
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  42 in total

1.  Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82.

Authors:  Robert Lafyatis; Julio C Mantero; Jessica Gordon; Nina Kishore; Mary Carns; Howard Dittrich; Robert Spiera; Robert W Simms; John Varga
Journal:  J Invest Dermatol       Date:  2017-08-12       Impact factor: 8.551

2.  Re-expression of pro-fibrotic, embryonic preserved mediators in irradiated arterial vessels of the head and neck region.

Authors:  Patrick Möbius; Raimund H M Preidl; Manuel Weber; Kerstin Amann; Friedrich W Neukam; Falk Wehrhan
Journal:  Strahlenther Onkol       Date:  2017-08-15       Impact factor: 3.621

3.  Transcriptomic Analysis of Human Mesenchymal Stem Cell Therapy in Incontinent Rat Injured Urethra.

Authors:  Zhina Sadeghi; Jonathan D Kenyon; Brian Richardson; Ahmad O Khalifa; Michael Cartwright; Britt Conroy; Arnold Caplan; Mark J Cameron; Adonis Hijaz
Journal:  Tissue Eng Part A       Date:  2020-07-02       Impact factor: 3.845

Review 4.  Drugs in phase I and phase II clinical trials for systemic sclerosis.

Authors:  Melody P Chung; Lorinda Chung
Journal:  Expert Opin Investig Drugs       Date:  2020-03-25       Impact factor: 6.206

5.  TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling.

Authors:  Dongqiang Yang; ShuJian Li; Xiaoxian Duan; Junling Ren; Shuang Liang; Lan Yakoumatos; Yi Kang; Silvia M Uriarte; Jia Shang; Wei Li; Huizhi Wang
Journal:  Mol Immunol       Date:  2019-12-26       Impact factor: 4.407

6.  Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis.

Authors:  Caressa Lietman; Brian Wu; Sarah Lechner; Andrew Shinar; Madhur Sehgal; Evgeny Rossomacha; Poulami Datta; Anirudh Sharma; Rajiv Gandhi; Mohit Kapoor; Pampee P Young
Journal:  JCI Insight       Date:  2018-02-08

7.  Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling.

Authors:  Hae-Kyung Lee; Eun-Woo Lee; Jinho Seo; Manhyung Jeong; Seon-Hyeong Lee; Soo-Youl Kim; Eek-Hoon Jho; Chel Hun Choi; Joon-Yong Chung; Jaewhan Song
Journal:  Oncogene       Date:  2018-05-01       Impact factor: 9.867

Review 8.  Converging Roles of the Aryl Hydrocarbon Receptor in Early Embryonic Development, Maintenance of Stemness, and Tissue Repair.

Authors:  Hesbon A Zablon; Chia-I Ko; Alvaro Puga
Journal:  Toxicol Sci       Date:  2021-07-16       Impact factor: 4.849

Review 9.  Cardiac fibrosis.

Authors:  Nikolaos G Frangogiannis
Journal:  Cardiovasc Res       Date:  2021-05-25       Impact factor: 10.787

Review 10.  An update on targeted therapies in systemic sclerosis based on a systematic review from the last 3 years.

Authors:  Corrado Campochiaro; Yannick Allanore
Journal:  Arthritis Res Ther       Date:  2021-06-01       Impact factor: 5.156
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