Literature DB >> 27334836

Tumor Microenvironment in Gene Signatures: Critical Biology or Confounding Noise?

Jeffrey S Morris1, Scott Kopetz2.   

Abstract

The tumor microenvironment contributes important information in gene expression signatures but may be susceptible to sampling variance. Mesenchymal signatures in particular may be influenced by sampling of nonrepresentative regions with high stromal content. Appropriate pathology quality control is required to ensure reproducibility of gene expression signatures. Clin Cancer Res; 22(16); 3989-91. ©2016 AACRSee related article by Dunne et al., p. 4095. ©2016 American Association for Cancer Research.

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Year:  2016        PMID： 27334836      PMCID： PMC4987158          DOI： 10.1158/1078-0432.CCR-16-1044

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  12 in total

1.  Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity.

Authors:  Tae-Min Kim; Seung-Hyun Jung; Chang Hyeok An; Sung Hak Lee; In-Pyo Baek; Min Sung Kim; Sung-Won Park; Je-Keun Rhee; Sug-Hyung Lee; Yeun-Jun Chung
Journal:  Clin Cancer Res       Date:  2015-05-15       Impact factor: 12.531

2.  Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer.

Authors:  Eva Karamitopoulou; Inti Zlobec; Ioannis Panayiotides; Efstratios S Patsouris; George Peros; George Rallis; Christos Lapas; Petros Karakitsos; Luigi M Terracciano; Alessandro Lugli
Journal:  Hum Pathol       Date:  2011-06-12       Impact factor: 3.466

3.  Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

Authors:  Philip D Dunne; Darragh G McArt; Conor A Bradley; Paul G O'Reilly; Helen L Barrett; Robert Cummins; Tony O'Grady; Ken Arthur; Maurice B Loughrey; Wendy L Allen; Simon S McDade; David J Waugh; Peter W Hamilton; Daniel B Longley; Elaine W Kay; Patrick G Johnston; Mark Lawler; Manuel Salto-Tellez; Sandra Van Schaeybroeck
Journal:  Clin Cancer Res       Date:  2016-05-05       Impact factor: 12.531

4.  A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition.

Authors:  Milena P Mak; Pan Tong; Lixia Diao; Robert J Cardnell; Don L Gibbons; William N William; Ferdinandos Skoulidis; Edwin R Parra; Jaime Rodriguez-Canales; Ignacio I Wistuba; John V Heymach; John N Weinstein; Kevin R Coombes; Jing Wang; Lauren Averett Byers
Journal:  Clin Cancer Res       Date:  2015-09-29       Impact factor: 12.531

5.  Overexpression of ZEB2 at the invasion front of colorectal cancer is an independent prognostic marker and regulates tumor invasion in vitro.

Authors:  Christoph Kahlert; Saleh Lahes; Praveen Radhakrishnan; Shamik Dutta; Carolin Mogler; Esther Herpel; Karsten Brand; Gunnar Steinert; Martin Schneider; Martin Mollenhauer; Christoph Reissfelder; Fee Klupp; Johannes Fritzmann; Christina Wunder; Axel Benner; Matthias Kloor; Cathrin Huth; Pietro Contin; Alexis Ulrich; Moritz Koch; Jürgen Weitz
Journal:  Clin Cancer Res       Date:  2011-10-31       Impact factor: 12.531

6.  Stromal gene expression defines poor-prognosis subtypes in colorectal cancer.

Authors:  Alexandre Calon; Enza Lonardo; Antonio Berenguer-Llergo; Elisa Espinet; Xavier Hernando-Momblona; Mar Iglesias; Marta Sevillano; Sergio Palomo-Ponce; Daniele V F Tauriello; Daniel Byrom; Carme Cortina; Clara Morral; Carles Barceló; Sebastien Tosi; Antoni Riera; Camille Stephan-Otto Attolini; David Rossell; Elena Sancho; Eduard Batlle
Journal:  Nat Genet       Date:  2015-02-23       Impact factor: 38.330

7.  Association between invasiveness, inflammatory reaction, desmoplasia and survival in colorectal cancer.

Authors:  T B Halvorsen; E Seim
Journal:  J Clin Pathol       Date:  1989-02       Impact factor: 3.411

8.  The value of immunohistochemistry for collagen IV expression in colorectal carcinomas.

Authors:  G J Offerhaus; F M Giardiello; J A Bruijn; T Stijnen; E N Molyvas; G J Fleuren
Journal:  Cancer       Date:  1991-01-01       Impact factor: 6.860

9.  Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study.

Authors:  Viktor H Koelzer; Pia Herrmann; Inti Zlobec; Eva Karamitopoulou; Alessandro Lugli; Ulrike Stein
Journal:  BMC Cancer       Date:  2015-03-21       Impact factor: 4.430

10.  The consensus molecular subtypes of colorectal cancer.

Authors:  Justin Guinney; Rodrigo Dienstmann; Xin Wang; Aurélien de Reyniès; Andreas Schlicker; Charlotte Soneson; Laetitia Marisa; Paul Roepman; Gift Nyamundanda; Paolo Angelino; Brian M Bot; Jeffrey S Morris; Iris M Simon; Sarah Gerster; Evelyn Fessler; Felipe De Sousa E Melo; Edoardo Missiaglia; Hena Ramay; David Barras; Krisztian Homicsko; Dipen Maru; Ganiraju C Manyam; Bradley Broom; Valerie Boige; Beatriz Perez-Villamil; Ted Laderas; Ramon Salazar; Joe W Gray; Douglas Hanahan; Josep Tabernero; Rene Bernards; Stephen H Friend; Pierre Laurent-Puig; Jan Paul Medema; Anguraj Sadanandam; Lodewyk Wessels; Mauro Delorenzi; Scott Kopetz; Louis Vermeulen; Sabine Tejpar
Journal:  Nat Med       Date:  2015-10-12       Impact factor: 53.440
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  7 in total

1.  Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data.

Authors:  Natalie C Fisher; Ryan M Byrne; Nigel B Jamieson; Philip D Dunne; Holly Leslie; Colin Wood; Assya Legrini; Andrew J Cameron; Baharak Ahmaderaghi; Shania M Corry; Sudhir B Malla; Raheleh Amirkhah; Aoife J McCooey; Emily Rogan; Keara L Redmond; Svetlana Sakhnevych; Enric Domingo; James Jackson; Maurice B Loughrey; Simon Leedham; Tim Maughan; Mark Lawler; Owen J Sansom; Felicity Lamrock; Viktor H Koelzer
Journal:  Clin Cancer Res       Date:  2022-09-15       Impact factor: 13.801

2.  KRAS Mutation and Consensus Molecular Subtypes 2 and 3 Are Independently Associated with Reduced Immune Infiltration and Reactivity in Colorectal Cancer.

Authors:  Neeraj Lal; Brian S White; Ghaleb Goussous; Oliver Pickles; Mike J Mason; Andrew D Beggs; Philippe Taniere; Benjamin E Willcox; Justin Guinney; Gary W Middleton
Journal:  Clin Cancer Res       Date:  2017-10-23       Impact factor: 12.531

3.  CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models.

Authors:  Peter W Eide; Jarle Bruun; Ragnhild A Lothe; Anita Sveen
Journal:  Sci Rep       Date:  2017-11-30       Impact factor: 4.379

4.  Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification.

Authors:  Philip D Dunne; Matthew Alderdice; Paul G O'Reilly; Aideen C Roddy; Amy M B McCorry; Susan Richman; Tim Maughan; Simon S McDade; Patrick G Johnston; Daniel B Longley; Elaine Kay; Darragh G McArt; Mark Lawler
Journal:  Nat Commun       Date:  2017-05-31       Impact factor: 14.919

5.  Epithelial-to-mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition.

Authors:  Amy Mb McCorry; Maurice B Loughrey; Daniel B Longley; Mark Lawler; Philip D Dunne
Journal:  J Pathol       Date:  2018-12       Impact factor: 7.996

6.  Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy.

Authors:  W L Allen; P D Dunne; S McDade; E Scanlon; M Loughrey; H Coleman; C McCann; K McLaughlin; Z Nemeth; N Syed; P Jithesh; K Arthur; R Wilson; V Coyle; D McArt; G I Murray; L Samuel; P Nuciforo; J Jimenez; G Argiles; R Dienstmann; J Tabernero; L Messerini; S Nobili; E Mini; K Sheahan; E Ryan; P G Johnston; S Van Schaeybroeck; M Lawler; D B Longley
Journal:  JCO Precis Oncol       Date:  2018-06-13

7.  A stroma-corrected ZEB1 transcriptional signature is inversely associated with antitumor immune activity in breast cancer.

Authors:  C James Block; Gregory Dyson; Ion John Campeanu; Donovan Watza; Manohar Ratnam; Guojun Wu
Journal:  Sci Rep       Date:  2019-11-28       Impact factor: 4.379
  7 in total

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