BACKGROUND: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. METHODS AND RESULTS: Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. CONCLUSIONS: HI in combination with TTM is a feasible therapy for patients with PCAS. (Circ J 2016; 80: 1870-1873).
BACKGROUND:Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for humanpatients with PCAS has never been studied. METHODS AND RESULTS: Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. CONCLUSIONS: HI in combination with TTM is a feasible therapy for patients with PCAS. (Circ J 2016; 80: 1870-1873).
Authors: Alexis R Cole; Dorothy A Perry; Ali Raza; Arthur P Nedder; Elizabeth Pollack; William L Regan; Sarah J van den Bosch; Brian D Polizzotti; Edward Yang; Daniel Davila; Onur Afacan; Simon K Warfield; Yangming Ou; Brenda Sefton; Allen D Everett; Jeffrey J Neil; Hart G W Lidov; John E Mayer; John N Kheir Journal: JACC Basic Transl Sci Date: 2019-03-27
Authors: Alexis R Cole; Ali Raza; Humera Ahmed; Brian D Polizzotti; Robert F Padera; Nick Andrews; John N Kheir Journal: Med Gas Res Date: 2019 Jul-Sep