BACKGROUND/AIMS: Small attention is paid to other types of bone diseases then chronic kidney disease-mineral and bone disorder in dialysis patients. The aim of our study was to assess the occurrence of osteoporosis and bone microarchitecture by trabecular bone score in this population. METHODS: 59 patients (67.6 ± 13.1 years, 43 males) treated with hemodiafIltration underwent densitometry (Lunar Prodigy, TBS software 2.1.2) and laboratory assessment. RESULTS: Osteoporosis was observed in 34% patients, high bone turnover was found in 80% of them, with SHPT (PTH > 300 ng/l) present in 69%. TBS was significantly decreased in 47.5% of the patients. TBS correlated with T- and Z-scores of the lumbar spine and proximal femur in the total population (P < 0.0001) and in men (P < 0.00001) and there were significant differences between TBS in groups with normal densitometry, osteopenia, and osteoporosis, both in total population (P < 0.0001; P < 0.01) and in men (P < 0.001; P < 0.001). CONCLUSIONS: Osteoporosis was found in about 1/3 of patients treated with hemodiafiltration. Normal TBS was found in only 1/4 of the dialysis population. TBS correlated with densitometric parameters and was significantly different relative to T-scores.
BACKGROUND/AIMS: Small attention is paid to other types of bone diseases then chronic kidney disease-mineral and bone disorder in dialysis patients. The aim of our study was to assess the occurrence of osteoporosis and bone microarchitecture by trabecular bone score in this population. METHODS: 59 patients (67.6 ± 13.1 years, 43 males) treated with hemodiafIltration underwent densitometry (Lunar Prodigy, TBS software 2.1.2) and laboratory assessment. RESULTS:Osteoporosis was observed in 34% patients, high bone turnover was found in 80% of them, with SHPT (PTH > 300 ng/l) present in 69%. TBS was significantly decreased in 47.5% of the patients. TBS correlated with T- and Z-scores of the lumbar spine and proximal femur in the total population (P < 0.0001) and in men (P < 0.00001) and there were significant differences between TBS in groups with normal densitometry, osteopenia, and osteoporosis, both in total population (P < 0.0001; P < 0.01) and in men (P < 0.001; P < 0.001). CONCLUSIONS:Osteoporosis was found in about 1/3 of patients treated with hemodiafiltration. Normal TBS was found in only 1/4 of the dialysis population. TBS correlated with densitometric parameters and was significantly different relative to T-scores.
Authors: Ludmila Brunerová; Petr Kasalický; Jana Verešová; Renata Lažanská; Jana Potočková; Ivan Rychlík Journal: Int Urol Nephrol Date: 2020-02-03 Impact factor: 2.370
Authors: M J Pérez-Sáez; S Herrera; D Prieto-Alhambra; L Vilaplana; X Nogués; M Vera; D Redondo-Pachón; M Mir; R Güerri; M Crespo; A Díez-Pérez; J Pascual Journal: Osteoporos Int Date: 2017-05-11 Impact factor: 4.507
Authors: Ludmila Brunerová; Renata Lažanská; Petr Kasalický; Jana Verešová; Jana Potočková; Alena Fialová; Ivan Rychlík Journal: Int Urol Nephrol Date: 2018-08-16 Impact factor: 2.370
Authors: Z Kužmová; M Kužma; A Gažová; M Kovářová; P Jackuliak; Z Killinger; J Kyselovič; J Payer Journal: Physiol Res Date: 2021-11-30 Impact factor: 1.881
Authors: Han Jo Kim; Alexander Dash; Matthew Cunningham; Frank Schwab; James Dowdell; Jonathan Harrison; Caroline Zaworski; Alexandra Krez; Virginie Lafage; Sanchita Agarwal; Brandon Carlson; Donald J McMahon; Emily M Stein Journal: Bone Date: 2020-11-04 Impact factor: 4.626