Literature DB >> 27332070

Cortisol, DHEA, and depression in the elderly: the influence of physical capacity.

Helena Moraes1,2, Andrea Deslandes1,3, Paulo de Tarso Maciel-Pinheiro1,4,5, Humberto Corrêa6, Jerson Laks2,7.   

Abstract

OBJECTIVE: Major depression have been associated with cortisol and dehydroepiandrosterone (DHEA) changes in old depressed patients. We examined the association between depression, cortisol, and DHEA, correcting for confounding variables, including physical capacity. In addition, the association between hormone levels and physical capacity in these two experimental groups was also analyzed.
METHOD: Depressed patients (n = 32) and healthy control (n = 31) old adults, both matched for age, were analyzed. Subjects were submitted to a physical capacity evaluation, including physical activity levels, functional fitness test, and balance scale.
RESULTS: Depressed patients showed significant lower levels of cortisol than controls, which became non-significant after controlling for physical capacity. A positive correlation was observed between cortisol levels and physical capacity.
CONCLUSIONS: The data suggest that physical capacity modulates the relationship between depression and cortisol levels and needs to be taken into consideration in the future investigations.

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Year:  2016        PMID: 27332070     DOI: 10.1590/0004-282X20160059

Source DB:  PubMed          Journal:  Arq Neuropsiquiatr        ISSN: 0004-282X            Impact factor:   1.420


  3 in total

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Authors:  Jasmine I Caulfield; Sonia A Cavigelli
Journal:  Front Neuroendocrinol       Date:  2019-11-04       Impact factor: 8.606

2.  Cortisol Reactivity to a physical stressor in Patients with Depression and Alzheimer's disease.

Authors:  Ana Beserra; Bruno Oliveira; Eduardo Portugal; Patrícia Dutra; Jerson Laks; Andrea Deslandes; Helena Moraes
Journal:  Dement Neuropsychol       Date:  2022 Jan-Mar

3.  Effects of Horticultural Therapy on Asian Older Adults: A Randomized Controlled Trial.

Authors:  Kheng Siang Ted Ng; Angelia Sia; Maxel K W Ng; Crystal T Y Tan; Hui Yu Chan; Chay Hoon Tan; Iris Rawtaer; Lei Feng; Rathi Mahendran; Anis Larbi; Ee Heok Kua; Roger C M Ho
Journal:  Int J Environ Res Public Health       Date:  2018-08-09       Impact factor: 3.390

  3 in total

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