Literature DB >> 27330489

Anxiety and Methylenetetrahydrofolate Reductase Mutation Treated With S-Adenosyl Methionine and Methylated B Vitamins.

Shanna Anderson1, Jacob Panka1, Robin Rakobitsch1, Kaitlin Tyre1, Kerry Pulliam1.   

Abstract

This case report highlights challenges faced in the clinical management of patients with methylenetetrahydrofolate reductase (MTHFR) gene mutations and the importance of precise dosage when recommending methylated B vitamins to compensate for deficiencies caused by the polymorphism or symptoms related to the polymorphism. It also underscores the importance of obtaining ongoing objective assessments of anxiety (eg, Patient Reported Outcomes Measurement Information System, or PROMIS) to help gauge patient response.

Entities:  

Year:  2016        PMID： 27330489      PMCID： PMC4898281     

Source DB:  PubMed          Journal:  Integr Med (Encinitas)        ISSN： 1546-993X


  15 in total

Review 1.  Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement.

Authors:  L B Bailey; J F Gregory
Journal:  J Nutr       Date:  1999-05       Impact factor: 4.798

2.  Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease.

Authors:  Elizabeth A Varga; Amy C Sturm; Caron P Misita; Stephan Moll
Journal:  Circulation       Date:  2005-05-17       Impact factor: 29.690

Review 3.  Complementary and alternative medicine for the treatment of major depressive disorder.

Authors:  Richard Nahas; Osmaan Sheikh
Journal:  Can Fam Physician       Date:  2011-06       Impact factor: 3.275

4.  Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life.

Authors:  Osvaldo P Almeida; Leon Flicker; Nicola T Lautenschlager; Peter Leedman; Samuel Vasikaran; Frank M van Bockxmeer
Journal:  Neurobiol Aging       Date:  2005-02       Impact factor: 4.673

Review 5.  The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis.

Authors:  S J Lewis; D A Lawlor; G Davey Smith; R Araya; N Timpson; I N M Day; S Ebrahim
Journal:  Mol Psychiatry       Date:  2006-04       Impact factor: 15.992

Review 6.  Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder.

Authors:  George I Papakostas
Journal:  J Clin Psychiatry       Date:  2009       Impact factor: 4.384

Review 7.  MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins?

Authors:  R Reilly; H McNulty; K Pentieva; J J Strain; M Ward
Journal:  Proc Nutr Soc       Date:  2013-10-17       Impact factor: 6.297

8.  S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS.

Authors:  R Andrew Shippy; Douglas Mendez; Kristina Jones; Irene Cergnul; Stephen E Karpiak
Journal:  BMC Psychiatry       Date:  2004-11-11       Impact factor: 3.630

Review 9.  Genetic polymorphisms in homocysteine metabolism and response to folate intake: a comprehensive strategy to elucidate useful genetic information.

Authors:  Koichi Miyaki
Journal:  J Epidemiol       Date:  2010-06-19       Impact factor: 3.211

10.  The effect of methylated vitamin B complex on depressive and anxiety symptoms and quality of life in adults with depression.

Authors:  John E Lewis; Eduard Tiozzo; Angelica B Melillo; Susanna Leonard; Lawrence Chen; Armando Mendez; Judi M Woolger; Janet Konefal
Journal:  ISRN Psychiatry       Date:  2013-01-21
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  1 in total

1.  Behavioral alterations are associated with vitamin B12 deficiency in the transcobalamin receptor/CD320 KO mouse.

Authors:  Kaveri Arora; Jeffrey M Sequeira; Alejandro I Hernández; Juan M Alarcon; Edward V Quadros
Journal:  PLoS One       Date:  2017-05-18       Impact factor: 3.240
  1 in total

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