Literature DB >> 27329433

Targeting the blood-spinal cord barrier: A therapeutic approach to spinal cord protection against ischemia-reperfusion injury.

Ji Hu1, Qijing Yu2, Lijie Xie3, Hongfei Zhu4.   

Abstract

One of the principal functions of physical barriers between the blood and central nervous system protects system (i.e., blood brain barrier and blood-spinal cord barrier) is the protection from toxic and pathogenic agents in the blood. Disruption of blood-spinal cord barrier (BSCB) plays a key role in spinal cord ischemia-reperfusion injury (SCIRI). Following SCIRI, the permeability of the BSCB increases. Maintaining the integrity of the BSCB alleviates the spinal cord injury after spinal cord ischemia. This review summarizes current knowledge of the structure and function of the BSCB and its changes following SCIRI, as well as the prevention and cure of SCIRI and the role of the BSCB.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Blood-spinal cord barrier; Reperfusion injury; Spinal cord ischemia

Mesh：

Year:  2016        PMID： 27329433     DOI： 10.1016/j.lfs.2016.06.018

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  11 in total

Review 1.  Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System.

Authors:  Jeffrey J Lochhead; Patrick T Ronaldson; Thomas P Davis
Journal:  AAPS J       Date:  2017-03-28       Impact factor: 4.009

2.  Perlecan Improves Blood Spinal Cord Barrier Repair Through the Integrin β1/ROCK/MLC Pathway After Spinal Cord Injury.

Authors:  Changnan Xie; Yihan Wang; Jinfeng Wang; Yizhou Xu; Haining Liu; Jiasong Guo; Lixin Zhu
Journal:  Mol Neurobiol       Date:  2022-10-10       Impact factor: 5.682

Review 3.  The roles of microRNAs in spinal cord ischemia-reperfusion injury.

Authors:  Feng-Shou Chen; Xiang-Yi Tong; Bo Fang; Dan Wang; Xiao-Qian Li; Zai-Li Zhang
Journal:  Neural Regen Res       Date:  2022-12       Impact factor: 6.058

4.  MiR-126-3p-Enriched Extracellular Vesicles from Hypoxia-Preconditioned VSC 4.1 Neurons Attenuate Ischaemia-Reperfusion-Induced Pain Hypersensitivity by Regulating the PIK3R2-Mediated Pathway.

Authors:  He Wang; Feng-Shou Chen; Zai-Li Zhang; Hong-Xu Zhou; Hong Ma; Xiao-Qian Li
Journal:  Mol Neurobiol       Date:  2020-10-08       Impact factor: 5.590

Review 5.  Hormonal therapy in traumatic spinal cord injury.

Authors:  Parker E Ludwig; Arun A Patil; Andrea J Chamczuk; Devendra K Agrawal
Journal:  Am J Transl Res       Date:  2017-09-15       Impact factor: 4.060

6.  Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway.

Authors:  Xiao-Qian Li; Qian Yu; Feng-Shou Chen; Wen-Fei Tan; Zai-Li Zhang; Hong Ma
Journal:  J Neuroinflammation       Date:  2018-09-01       Impact factor: 8.322

7.  Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization.

Authors:  Ran Li; Kunchi Zhao; Qing Ruan; Chunyang Meng; Fei Yin
Journal:  Arthritis Res Ther       Date:  2020-04-09       Impact factor: 5.156

Review 8.  Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis.

Authors:  G Y Wang; S L Rayner; R Chung; B Y Shi; X J Liang
Journal:  Mater Today Bio       Date:  2020-05-04

Review 9.  Regulation of inflammatory cytokines for spinal cord injury recovery.

Authors:  Sen Lin; Chang Xu; Jiaquan Lin; Hengshuo Hu; Chuanjie Zhang; Xifan Mei
Journal:  Histol Histopathol       Date:  2020-10-01       Impact factor: 2.303

Review 10.  Therapeutic Potential of Mesenchymal Stem Cells (MSCs) and MSC-Derived Extracellular Vesicles for the Treatment of Spinal Cord Injury.

Authors:  Gang-Un Kim; Soo-Eun Sung; Kyung-Ku Kang; Joo-Hee Choi; Sijoon Lee; Minkyoung Sung; Seung Yun Yang; Seul-Ki Kim; Young In Kim; Ju-Hyeon Lim; Min-Soo Seo; Gun Woo Lee
Journal:  Int J Mol Sci       Date:  2021-12-20       Impact factor: 5.923
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.