Literature DB >> 2732775

The alternative hypothesis: one-sided or two-sided?

K E Peace1.   

Abstract

The appropriateness of a one-sided alternative hypothesis rather than the more conservative, boiler-plate, two-sided hypothesis is discussed and examples provided. It is concluded that confirmatory efficacy clinical trials of pharmaceutical compounds should always be viewed within the one-sided alternative hypothesis testing framework.

Mesh:

Year:  1989        PMID: 2732775     DOI: 10.1016/0895-4356(89)90137-6

Source DB:  PubMed          Journal:  J Clin Epidemiol        ISSN: 0895-4356            Impact factor:   6.437


  3 in total

1.  Confidence intervals: from statistical significance to clinical significance.

Authors:  P P Morgan
Journal:  CMAJ       Date:  1989-11-01       Impact factor: 8.262

2.  Is the effect of work-related psychosocial exposure on depressive and anxiety disorders short-term, lagged or cumulative?

Authors:  Stéphanie Boini; Martin Kolopp; Michel Grzebyk; Guy Hédelin; Dominique Chouanière
Journal:  Int Arch Occup Environ Health       Date:  2019-08-03       Impact factor: 3.015

Review 3.  An assessment of recently published gene expression data analyses: reporting experimental design and statistical factors.

Authors:  Peyman Jafari; Francisco Azuaje
Journal:  BMC Med Inform Decis Mak       Date:  2006-06-21       Impact factor: 2.796

  3 in total

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