| Literature DB >> 27327298 |
Saeid Alinezhad, Riina-Minna Väänänen, Jesse Mattsson, Yifeng Li, Terhi Tallgrén, Natalia Tong Ochoa, Anders Bjartell, Malin Åkerfelt, Pekka Taimen, Peter J Boström, Kim Pettersson, Matthias Nees.
Abstract
[This corrects the article DOI: 10.1371/journal.pone.0155901.].Entities:
Year: 2016 PMID: 27327298 PMCID: PMC4915716 DOI: 10.1371/journal.pone.0158255
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Fig 8Images of 3D organotypic cell cultures of PC3 cells, embed in Matrigel, after segmentation and subsequent image analysis using the AMIDA software package
A. Untreated cells form large organoids with overt invasive processes. B. Silencing of PLA2G7 and C. laminin beta 1 (LMNB1) result in well-rounded, poorly invasive organoids, with higher cell density. D. In contrast, silencing of the TDRD1 gene results in significant induction of invasive properties, further loss of the structural organization or maturation of organoids, and decreased cell density.