BACKGROUND/AIMS: The hydrating properties of three moisturising preparations, commonly recommended for the treatment of dry skin, were compared by utilising non-invasive measuring methods. METHODS: The preparations were Decubal®/Abitima® cream, Dumex Ltd; pH5-Eucerin® ointment, Beiersdorf; and Essex® cream, Schering Plough. Skicon-200® and a Corneometer CM 420® were used for assessment of skin hydration. Readings of the transepidermal water loss (TEWL) and skin temperature were also taken. The study was conducted in 2 parts, each with 12 women. The preparations were applied to a designated area on the forearms 2× a day for 7 days; the 4th, untreated, area served as control. Readings were taken before the start of treatment and every morning during the treatment period and the following week. RESULTS: Both electrical measuring methods showed that hydration of the stratum corneum increased after a few days of treatment, especially after the application of Decubal®/Abitima®. TEWL was not affected by any of the treatments. CONCLUSIONS: The two electrical methods ranked the products consistently, i.e. Decubal®/Abitima® >pH5-Eucerin® >Essex®. Conductance (Skicon-200) was more discriminative than capacitance (Corneometer CM420). However, these methods are not water specific. TEWL was not affected by the treatments.
BACKGROUND/AIMS: The hydrating properties of three moisturising preparations, commonly recommended for the treatment of dry skin, were compared by utilising non-invasive measuring methods. METHODS: The preparations were Decubal®/Abitima® cream, Dumex Ltd; pH5-Eucerin® ointment, Beiersdorf; and Essex® cream, Schering Plough. Skicon-200® and a Corneometer CM 420® were used for assessment of skin hydration. Readings of the transepidermal water loss (TEWL) and skin temperature were also taken. The study was conducted in 2 parts, each with 12 women. The preparations were applied to a designated area on the forearms 2× a day for 7 days; the 4th, untreated, area served as control. Readings were taken before the start of treatment and every morning during the treatment period and the following week. RESULTS: Both electrical measuring methods showed that hydration of the stratum corneum increased after a few days of treatment, especially after the application of Decubal®/Abitima®. TEWL was not affected by any of the treatments. CONCLUSIONS: The two electrical methods ranked the products consistently, i.e. Decubal®/Abitima® >pH5-Eucerin® >Essex®. Conductance (Skicon-200) was more discriminative than capacitance (Corneometer CM420). However, these methods are not water specific. TEWL was not affected by the treatments.
Authors: Manfred Bodenlenz; Thomas Augustin; Thomas Birngruber; Katrin I Tiffner; Beate Boulgaropoulos; Simon Schwingenschuh; Sam G Raney; Elena Rantou; Frank Sinner Journal: Pharm Res Date: 2020-09-28 Impact factor: 4.200