Markus K Schuler1, Leopold Hentschel2, Julia Göbel3, Ekaterina Balaian3, Beate Hornemann4, Julia Hoffmann5, Michael Kramer3, Philip Kasten6, Martin Bornhäuser3, Gerhard Ehninger7, Uwe Platzbecker8. 1. Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; University Cancer Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Clinic for Internal Medicine II, HELIOS Hospital Emil von Behring, Walterhöferstraße 11, 14165 Berlin, Germany. 2. University Cancer Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address: Leopold.Hentschel@uniklinikum-dresden.de. 3. Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 4. University Cancer Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 5. University Physiotherapy Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 6. Department of Sports Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Practice for Orthopedics and Orthopedic Surgery, Tübingen, Germany. 7. Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; University Cancer Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 8. Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address: Uwe.Platzbecker@uniklinikum-dresden.de.
Abstract
INTRODUCTION: Fatigue is a frequent and disabling symptom in myelodysplastic syndromes (MDS). There is evidence for the benefit of exercise on fatigue in haematological malignancies, but clinical trials targeting patients with MDS do not exist. METHODS: A prospective, non-randomized feasibility trial was conducted to assess the safety and efficacy of a home-based exercise intervention in patients with MDS. Exercise schedule contained endurance or strength training in daily turns over 12 weeks. Outcome measures included 6-min walking distance (6-MWD), an ergometer check, strength measurement of lower limb, abdomen and back, quality of life and fatigue. RESULTS: Twenty-one patients (13 male, 8 female) were included. Median age was 66 years (range 29-87). Fifteen patients (71%) continued the program till week 12 (T1), of whom eleven patients met criteria for program completion. There were no adverse events reported due to the intervention. 6-MWD significantly improved from 580m at T0 to 645m at T1 (p<0.05). Fatigue scores did not significantly change over time (MFI: 12.8 vs. 12.3 vs. 11.9; QLQ-C30 fatigue scale: 48.2 vs. 46.7 vs. 47.4). CONCLUSION: These data provide evidence that an unsupervised outpatient exercise program is feasible and can improve physical capacity. Randomized, controlled studies implementing these interventions are warranted.
INTRODUCTION:Fatigue is a frequent and disabling symptom in myelodysplastic syndromes (MDS). There is evidence for the benefit of exercise on fatigue in haematological malignancies, but clinical trials targeting patients with MDS do not exist. METHODS: A prospective, non-randomized feasibility trial was conducted to assess the safety and efficacy of a home-based exercise intervention in patients with MDS. Exercise schedule contained endurance or strength training in daily turns over 12 weeks. Outcome measures included 6-min walking distance (6-MWD), an ergometer check, strength measurement of lower limb, abdomen and back, quality of life and fatigue. RESULTS: Twenty-one patients (13 male, 8 female) were included. Median age was 66 years (range 29-87). Fifteen patients (71%) continued the program till week 12 (T1), of whom eleven patients met criteria for program completion. There were no adverse events reported due to the intervention. 6-MWD significantly improved from 580m at T0 to 645m at T1 (p<0.05). Fatigue scores did not significantly change over time (MFI: 12.8 vs. 12.3 vs. 11.9; QLQ-C30 fatigue scale: 48.2 vs. 46.7 vs. 47.4). CONCLUSION: These data provide evidence that an unsupervised outpatient exercise program is feasible and can improve physical capacity. Randomized, controlled studies implementing these interventions are warranted.
Authors: Kah Poh Loh; Chandrika Sanapala; Grace Di Giovanni; Heidi D Klepin; Michelle Janelsins; Rebecca Schnall; Eva Culakova; Paula Vertino; Martha Susiarjo; Jason H Mendler; Jane L Liesveld; Po-Ju Lin; Richard F Dunne; Ian Kleckner; Karen Mustian; Supriya G Mohile Journal: J Geriatr Oncol Date: 2021-03-04 Impact factor: 3.929
Authors: Kah Poh Loh; Chandrika Sanapala; Michelle Janelsins; Heidi D Klepin; Rebecca Schnall; Eva Culakova; Michael B Sohn; Paula Vertino; Martha Susiarjo; Marielle Jensen-Battaglia; Michael W Becker; Jane Liesveld; Jason H Mendler; Eric Huselton; Po-Ju Lin; Karen Mustian Journal: J Geriatr Oncol Date: 2021-12-21 Impact factor: 3.929
Authors: Kah Poh Loh; Chandrika Sanapala; Erin Elizabeth Watson; Marielle Jensen-Battaglia; Michelle C Janelsins; Heidi D Klepin; Rebecca Schnall; Eva Culakova; Paula Vertino; Martha Susiarjo; Po-Ju Lin; Jason H Mendler; Jane L Liesveld; Eric J Huselton; Kathryn Taberner; Supriya G Mohile; Karen Mustian Journal: Blood Adv Date: 2022-07-12