Wen Ni Tiong1, Alan Yean Yip Fong2, Edmund Ui Hang Sim3, Hiang Chuan Chan4, Tiong Kiam Ong5, Boon Cheng Chang5, Kui Hian Sim5. 1. Clinical Research Centre, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia; Department of Molecular Biology, University Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia. 2. Clinical Research Centre, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia; Department of Cardiology, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia. 3. Department of Molecular Biology, University Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia. 4. Accident and Emergency Department, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia. 5. Department of Cardiology, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia.
Abstract
OBJECTIVE: Interleukin-6 (IL6; proinflammatory marker), von Willebrand Factor (vWF; endothelial dysfunction marker) and P-selectin (platelet activation marker), may play important roles in defining the pathogenesis of vulnerable plaques in acute coronary syndrome (ACS). This study aims to investigate the expression and relationship of these markers in early phases of ACS in a young and multiethnic Malaysian population. DESIGN: Peripheral whole blood mRNA, and serum levels of IL6, vWF and P-selectin were measured in 22 patients with ACS, and in 28 controls with angiographically significant coronary artery disease without previous ACS events. Venous blood from ACS patients was obtained within 1 h of hospital admission. RESULTS: No significant differences of IL6, vWF and P-selectin mRNA levels between ACS and controls were seen. ACS patients had significantly higher serum levels of IL6 and vWF (p<0.001), compared with controls. P-selectin correlated with IL6 (r=0.697, p=0.003) and vWF (r=0.497, p=0.05) at mRNA levels, indicating a possible association between these three indices of ACS pathogenesis. CONCLUSIONS: Increased serum levels of IL6 and vWF suggest that inflammation and endothelial dysfunction may play a prominent role in the pathogenesis of the disease during the early phase of ACS.
OBJECTIVE:Interleukin-6 (IL6; proinflammatory marker), von Willebrand Factor (vWF; endothelial dysfunction marker) and P-selectin (platelet activation marker), may play important roles in defining the pathogenesis of vulnerable plaques in acute coronary syndrome (ACS). This study aims to investigate the expression and relationship of these markers in early phases of ACS in a young and multiethnic Malaysian population. DESIGN: Peripheral whole blood mRNA, and serum levels of IL6, vWF and P-selectin were measured in 22 patients with ACS, and in 28 controls with angiographically significant coronary artery disease without previous ACS events. Venous blood from ACS patients was obtained within 1 h of hospital admission. RESULTS: No significant differences of IL6, vWF and P-selectin mRNA levels between ACS and controls were seen. ACS patients had significantly higher serum levels of IL6 and vWF (p<0.001), compared with controls. P-selectin correlated with IL6 (r=0.697, p=0.003) and vWF (r=0.497, p=0.05) at mRNA levels, indicating a possible association between these three indices of ACS pathogenesis. CONCLUSIONS: Increased serum levels of IL6 and vWF suggest that inflammation and endothelial dysfunction may play a prominent role in the pathogenesis of the disease during the early phase of ACS.
Authors: Rick D Fannin; J Todd Auman; Maribel E Bruno; Stella O Sieber; Sandra M Ward; Charles J Tucker; B Alex Merrick; Richard S Paules Journal: Physiol Genomics Date: 2005-03-21 Impact factor: 3.107
Authors: Hector A Cabrera-Fuentes; Julian Aragones; Jürgen Bernhagen; Andreas Boening; William A Boisvert; Hans E Bøtker; Heerajnarain Bulluck; Stuart Cook; Fabio Di Lisa; Felix B Engel; Bernd Engelmann; Fulvia Ferrazzi; Péter Ferdinandy; Alan Fong; Ingrid Fleming; Erich Gnaiger; Sauri Hernández-Reséndiz; Siavash Beikoghli Kalkhoran; Moo Hyun Kim; Sandrine Lecour; Elisa A Liehn; Michael S Marber; Manuel Mayr; Tetsuji Miura; Sang-Bing Ong; Karlheinz Peter; Daniel Sedding; Manvendra K Singh; M Saadeh Suleiman; Hans J Schnittler; Rainer Schulz; Winston Shim; Daniel Tello; Carl-Wilhelm Vogel; Malcolm Walker; Qilong Oscar Yang Li; Derek M Yellon; Derek J Hausenloy; Klaus T Preissner Journal: Basic Res Cardiol Date: 2016-10-14 Impact factor: 17.165