OBJECTIVE: The purpose of this study was to elucidate the role of ghrelin after acute myocardial infarction (AMI) in left ventricular (LV) remodelling. DESIGN: Prospective observational study. SETTING: Jichi Medical University Hospital. PATIENTS: Fifty consecutive patients experiencing their first AMI. INTERVENTIONS: Ghrelin was measured on the day of admission, day 7, day 14 and 6 months after AMI. Patients were treated by percutaneous coronary intervention, and successful myocardial reperfusion was accomplished within 12 h after onset. To analyse LV remodelling, the authors performed left ventriculographies on the day of admission and 6 months after AMI. MAIN OUTCOME MEASURES: Changes in LV volume. RESULTS: Plasma ghrelin increased significantly after AMI (admission: 40.9±7.3; day 7: 89.5±11.0; day 14: 92.6±11.8 fmol/ml, p<0.0001). There was a significant correlation between ghrelin on day 14 and changes in LV volume over 6 months (r=+0.46, p<0.001). Multivariate regression analysis showed that ghrelin on day 14 is a significant predictor of LV remodelling after AMI (β=+0.44, p=0.001). CONCLUSION: To our knowledge, this is the first report that shows a relation between circulating ghrelin after AMI and the progression of LV remodelling in the chronic phase. The elevation of ghrelin after AMI might be a compensatory mechanism to attenuate LV remodelling.
OBJECTIVE: The purpose of this study was to elucidate the role of ghrelin after acute myocardial infarction (AMI) in left ventricular (LV) remodelling. DESIGN: Prospective observational study. SETTING: Jichi Medical University Hospital. PATIENTS: Fifty consecutive patients experiencing their first AMI. INTERVENTIONS:Ghrelin was measured on the day of admission, day 7, day 14 and 6 months after AMI. Patients were treated by percutaneous coronary intervention, and successful myocardial reperfusion was accomplished within 12 h after onset. To analyse LV remodelling, the authors performed left ventriculographies on the day of admission and 6 months after AMI. MAIN OUTCOME MEASURES: Changes in LV volume. RESULTS: Plasma ghrelin increased significantly after AMI (admission: 40.9±7.3; day 7: 89.5±11.0; day 14: 92.6±11.8 fmol/ml, p<0.0001). There was a significant correlation between ghrelin on day 14 and changes in LV volume over 6 months (r=+0.46, p<0.001). Multivariate regression analysis showed that ghrelin on day 14 is a significant predictor of LV remodelling after AMI (β=+0.44, p=0.001). CONCLUSION: To our knowledge, this is the first report that shows a relation between circulating ghrelin after AMI and the progression of LV remodelling in the chronic phase. The elevation of ghrelin after AMI might be a compensatory mechanism to attenuate LV remodelling.
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Keywords:
AMI; Acute coronary syndrome; Acute coronary syndromes; BMI; C-reactive protein; CPK-AUC; CRP; GH; Ghrelin; IGF-1; LV; LVEDVI; LVEF; Metabolism; Myocardial ischaemia; PCI; Ventricular remodelling; acute myocardial infarction; body mass index; creatine phosphokinase-area under the curve; growth hormone; insulin-like growth factor-1; left ventricular; left ventricular ejection fraction; left ventricular end-diastolic volume index; percutaneous coronary intervention
Authors: S D Anker; A L Clark; M Kemp; C Salsbury; M M Teixeira; P G Hellewell; A J Coats Journal: J Am Coll Cardiol Date: 1997-10 Impact factor: 24.094
Authors: John K Ninomiya; Gilbert L'Italien; Michael H Criqui; Joanna L Whyte; Anthony Gamst; Roland S Chen Journal: Circulation Date: 2003-12-15 Impact factor: 29.690