| Literature DB >> 27324978 |
Hong Dai1, Gang Li1, Jia Chen1, Yujun Shi2, Shushan Ge1, Chongguang Fan1, Haibing He3.
Abstract
A new library of 1,3,4-thiadiazole-containing pyrazole oximes was designed and synthesized. Their acaricidal and insecticidal activities were evaluated. Bioassay results indicated that some target compounds exhibited good acaricidal and insecticidal properties. Especially, compound 8m had 80% acaricidal activity against Tetranychus cinnabarinus at the concentration of 50μg/mL, compound 8f displayed 100% insecticidal activities against Aphis craccivora at the concentration of 50μg/mL, compounds 8r and 8w showed 100% insecticidal activities against Plutella xylostella at the concentration of 50μg/mL. Furthermore, compounds 8r (LC50=19.61μg/mL) and 8w (LC50=9.78μg/mL) possessed comparable or even better insecticidal activities than the control Pyridalyl (LC50=17.40μg/mL) against P. xylostella.Entities:
Keywords: 1,3,4-Thiadiazole; Bioactivity; Pyrazole oxime; Synthesis
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Year: 2016 PMID： 27324978 DOI： 10.1016/j.bmcl.2016.04.094
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823