Literature DB >> 27324639

Pleiotropic and retinoprotective functions of PACAP.

Seiji Shioda1, Fumiko Takenoya2, Nobuhiro Wada2, Takahiro Hirabayashi2, Tamotsu Seki3, Tomoya Nakamachi4.   

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues of the eye, including the retina, cornea and lacrimal gland, and PACAP is known to exert pleiotropic effects throughout the central nervous system. This review provides an overview of current knowledge regarding the cell protective effects, mechanisms of action and therapeutic potential of PACAP in response to several types of eye injury.

Entities:  

Keywords:  Dry eye; Neurotropic function; PACAP; Retinoprotection

Mesh：

Substances：

Year:  2016        PMID： 27324639     DOI： 10.1007/s12565-016-0351-0

Source DB:  PubMed          Journal:  Anat Sci Int        ISSN： 1447-073X            Impact factor:   1.741


  14 in total

1.  Distribution of PACAP and PAC1 Receptor in the Human Eye.

Authors:  Evelin Patko; Edina Szabo; Denes Toth; Tamas Tornoczky; Inez Bosnyak; Alexandra Vaczy; Tamas Atlasz; Dora Reglodi
Journal:  J Mol Neurosci       Date:  2022-03-07       Impact factor: 3.444

2.  The Protective Role of PAC1-Receptor Agonist Maxadilan in BCCAO-Induced Retinal Degeneration.

Authors:  A Vaczy; D Reglodi; T Somoskeoy; K Kovacs; E Lokos; E Szabo; A Tamas; T Atlasz
Journal:  J Mol Neurosci       Date:  2016-08-26       Impact factor: 3.444

3.  Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents.

Authors:  Dora Werling; William A Banks; Therese S Salameh; Timea Kvarik; Laszlo Akos Kovacs; Alexandra Vaczy; Edina Szabo; Flora Mayer; Rita Varga; Andrea Tamas; Gabor Toth; Zsolt Biro; Tamas Atlasz; Dora Reglodi
Journal:  Int J Mol Sci       Date:  2017-03-21       Impact factor: 5.923

Review 4.  Protective effects of PACAP in ischemia.

Authors:  Dora Reglodi; Alexandra Vaczy; Eloísa Rubio-Beltran; Antoinette MaassenVanDenBrink
Journal:  J Headache Pain       Date:  2018-03-02       Impact factor: 7.277

5.  Spatiotemporal Characterization of Anterior Segment Mesenchyme Heterogeneity During Zebrafish Ocular Anterior Segment Development.

Authors:  Kristyn L Van Der Meulen; Oliver Vöcking; Megan L Weaver; Nishita N Meshram; Jakub K Famulski
Journal:  Front Cell Dev Biol       Date:  2020-05-27

6.  Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.

Authors:  Daniel Balazs Fulop; Viktoria Humli; Judit Szepesy; Virag Ott; Dora Reglodi; Balazs Gaszner; Adrienn Nemeth; Agnes Szirmai; Laszlo Tamas; Hitoshi Hashimoto; Tibor Zelles; Andrea Tamas
Journal:  Sci Rep       Date:  2019-10-10       Impact factor: 4.379

Review 7.  Delivery Systems of Retinoprotective Proteins in the Retina.

Authors:  Ivan T Rebustini; Alexandra Bernardo-Colón; Alejandra Isasi Nalvarte; S Patricia Becerra
Journal:  Int J Mol Sci       Date:  2021-05-19       Impact factor: 5.923

Review 8.  Discovery of PACAP and its receptors in the brain.

Authors:  Takahiro Hirabayashi; Tomoya Nakamachi; Seiji Shioda
Journal:  J Headache Pain       Date:  2018-04-04       Impact factor: 7.277

9.  Inhibition of retinal ganglion cell apoptosis: regulation of mitochondrial function by PACAP.

Authors:  Huan-Huan Cheng; Hui Ye; Rui-Ping Peng; Juan Deng; Yong Ding
Journal:  Neural Regen Res       Date:  2018-05       Impact factor: 5.135

Review 10.  Relationships Between Neurodegeneration and Vascular Damage in Diabetic Retinopathy.

Authors:  Maria Grazia Rossino; Massimo Dal Monte; Giovanni Casini
Journal:  Front Neurosci       Date:  2019-11-08       Impact factor: 4.677
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