Mirjam Stahl1, Christian Holfelder2, Carolin Kneppo3, Meinhard Kieser4, Christian Kasperk5, Eckhard Schoenau6, Olaf Sommerburg7, Burkhard Tönshoff3. 1. Division of Pediatric Pulmonology, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany. Electronic address: mirjam.stahl@med.uni-heidelberg.de. 2. Department of Pediatric Radiology, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany. 3. Department of Pediatrics I, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany. 4. Institute of Medical Biometry and Informatics, University Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany. 5. Department of Medicine I, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. 6. Children's Hospital, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. 7. Division of Pediatric Pulmonology, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.
Abstract
BACKGROUND: The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. METHODS: In a cross-sectional study of 43 CF patients (age, 17.8±6.2years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated. RESULTS: The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CF patients at 25years was reduced to 39.8% compared to 84.6% in controls (P<0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%). CONCLUSIONS: Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CF patients.
BACKGROUND: The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. METHODS: In a cross-sectional study of 43 CFpatients (age, 17.8±6.2years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated. RESULTS: The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CFpatients at 25years was reduced to 39.8% compared to 84.6% in controls (P<0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%). CONCLUSIONS: Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CFpatients.
Authors: Wang Shin Lei; Marissa J Kilberg; Babette S Zemel; Ronald C Rubenstein; Clea Harris; Saba Sheikh; Andrea Kelly; Joseph M Kindler Journal: J Clin Transl Endocrinol Date: 2022-09-03