Ben Ali Gannoun Marwa1, Nozha Raguema2, Hedia Zitouni2, Hachani Ben Ali Feten3, Kacem Olfa3, Raja Elfeleh4, Wassim Almawi5, Touhami Mahjoub6. 1. Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy of Monastir, University of Monastir, Tunisia; Faculty of Science of Bizerte, University of Carthage, Tunisia. Electronic address: marwabenali24@yahoo.fr. 2. Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy of Monastir, University of Monastir, Tunisia; Faculty of Science of Bizerte, University of Carthage, Tunisia. 3. University Hospital F. Hached, Department of Obstetrics and Gynaecology, Sousse, Tunisia. 4. Centre of Maternity and Neonatology, Monastir, Tunisia. 5. Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. 6. Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy of Monastir, University of Monastir, Tunisia.
Abstract
BACKGROUND: Fibroblast growth factor (FGF) 1 and FGF2 were previously linked with preeclampsia (PE), possibly through altering decidual and placental FGFR2 expression. Since common variation in FGF1 and FGF2 might influence FGF1 and FGF2 activity, this study evaluated whether common FGF1 and FGF2 variants are linked with PE and associated features. METHODS: The association between FGF1 rs34011 and FGF2 rs2922979 SNPs and PE were tested in 300 women with PE, and 300 age-matched control women. RESULTS: The allelic distribution of FGF1 rs34011 (P < 0.001) but not FGF2 rs2922979, variants were significantly different between PE cases and control women. Marginal association of FGF2 rs2922979 was seen after controlling for key covariates. Setting homozygous major allele genotype (1/1) as reference, significantly higher frequencies of heterozygous rs345011, and reduced frequency of heterozygous rs2922979 genotype carriers were seen in PE cases; the distribution of the remaining genotypes were comparable between cases and controls. Carriage of rs2922979 minor allele correlated with fasting glucose (P = 0.02), while the presence of rs34011 minor allele was not correlated with PE-associated features. CONCLUSIONS: Our study suggests that the genetic variants of FGF1 rs34011, more so than FGF2 rs2922979, may play a role in PE pathogenesis in Tunisian women. These findings need confirmation in other ethnic populations.
BACKGROUND:Fibroblast growth factor (FGF) 1 and FGF2 were previously linked with preeclampsia (PE), possibly through altering decidual and placental FGFR2 expression. Since common variation in FGF1 and FGF2 might influence FGF1 and FGF2 activity, this study evaluated whether common FGF1 and FGF2 variants are linked with PE and associated features. METHODS: The association between FGF1rs34011 and FGF2rs2922979 SNPs and PE were tested in 300 women with PE, and 300 age-matched control women. RESULTS: The allelic distribution of FGF1rs34011 (P < 0.001) but not FGF2rs2922979, variants were significantly different between PE cases and control women. Marginal association of FGF2rs2922979 was seen after controlling for key covariates. Setting homozygous major allele genotype (1/1) as reference, significantly higher frequencies of heterozygous rs345011, and reduced frequency of heterozygous rs2922979 genotype carriers were seen in PE cases; the distribution of the remaining genotypes were comparable between cases and controls. Carriage of rs2922979 minor allele correlated with fasting glucose (P = 0.02), while the presence of rs34011 minor allele was not correlated with PE-associated features. CONCLUSIONS: Our study suggests that the genetic variants of FGF1rs34011, more so than FGF2rs2922979, may play a role in PE pathogenesis in Tunisian women. These findings need confirmation in other ethnic populations.
Authors: Akriti S Sahay; Anjali T Jadhav; Deepali P Sundrani; Girija N Wagh; Savita S Mehendale; Preeti Chavan-Gautam; Sadhana R Joshi Journal: Mol Cell Biochem Date: 2017-08-02 Impact factor: 3.396
Authors: Karen K Mestan; Nina Gotteiner; Nicolas Porta; William Grobman; Emily J Su; Linda M Ernst Journal: J Pediatr Date: 2017-02-02 Impact factor: 4.406