| Literature DB >> 27323802 |
Kenta Iwasaki1, Takayuki Yamamoto2, Yukiko Inanaga3, Takahisa Hiramitsu2, Yuko Miwa3, Kenta Murotani4, Shuji Narumi2, Yoshihiko Watarai2, Akio Katayama5, Kazuharu Uchida1,6, Takaaki Kobayashi6.
Abstract
De novo donor-specific HLA antibody (DSA) would not necessarily contribute to chronic antibody-mediated rejection (CAMR) in kidney transplantation. Here, we investigated whether PBMC miRNAs could be predictable biomarkers for CAMR. Microarray profiling of 435 mature miRNAs in pooled samples was conducted. Individual analysis revealed that miR-142-5p was significantly (p < 0.01) underexpressed in patients with DSA. After DSA production, miR-486-5p and its target PTEN/foxO3 mRNA were significantly overexpressed (p < 0.01) and underexpressed (p < 0.01), respectively, in patients with biopsy-proven CAMR, compared with non-CAMR. Our studies suggest that miRNA expression patterns may serve as noninvasive diagnostic biomarkers to evaluate immune response and kidney allograft status.Entities:
Keywords: Chronic antibody-mediated rejection; diagnosis; kidney transplantation; microRNA
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Year: 2016 PMID： 27323802 DOI： 10.1080/1354750X.2016.1204000
Source DB: PubMed Journal: Biomarkers ISSN： 1354-750X Impact factor: 2.658