William T Zempsky1, Emily O Wakefield, James P Santanelli, Tamara New, Kimberly Smith-Whitley, James F Casella, Tonya M Palermo. 1. *Connecticut Children's Medical Center ‡Institute of Living at Hartford Hospital, Hartford †University of Connecticut School of Medicine, Farmington, CT §Children's Healthcare of Atlanta at Emory University School of Medicine, Atlanta, GA ∥Children's Hospital of Philadelphia, Philadelphia, PA ¶Johns Hopkins School of Medicine, Baltimore, MA #University of Washington and Seattle Children's Research Institute, Seattle, WA.
Abstract
OBJECTIVES: The purpose of this study was to describe the clinical phenotype of widespread pain (WSP) among youth with sickle cell disease (SCD) hospitalized with vasoocclusive pain. MATERIALS AND METHODS: One hundred fifty-six youth with SCD, between 7 and 21 years of age hospitalized at 4 children's hospitals for a vasoocclusive episode were evaluated. Data were collected during 1 day of the hospitalization. RESULTS: Using the 2010 American College of Rheumatology guidelines, 21.8% of patients were identified as having WSP (pain in 7 or more unique body locations). Patients classified as having WSP had higher pain intensity (6.5 vs. 5.6; t=2.19, P=0.03) higher pain burden (13.0 vs. 9.8; t=3.09, P=0.002), higher acute functional disability (22.1 vs. 16.5; t=2.43, P=0.016), higher chronic functional disability (30.4 vs. 22.2; t=2.31, P=0.02), lower positive affect (22.9 vs. 27.6; t=2.23, P=0.027), and lower quality of life (56.2 vs. 62.9; t=1.99, P=0.049) than those youth with SCD without WSP. DISCUSSION: Assessment of WSP may identify a unique clinical phenotype of youth with SCD with differing treatment needs.
OBJECTIVES: The purpose of this study was to describe the clinical phenotype of widespread pain (WSP) among youth with sickle cell disease (SCD) hospitalized with vasoocclusive pain. MATERIALS AND METHODS: One hundred fifty-six youth with SCD, between 7 and 21 years of age hospitalized at 4 children's hospitals for a vasoocclusive episode were evaluated. Data were collected during 1 day of the hospitalization. RESULTS: Using the 2010 American College of Rheumatology guidelines, 21.8% of patients were identified as having WSP (pain in 7 or more unique body locations). Patients classified as having WSP had higher pain intensity (6.5 vs. 5.6; t=2.19, P=0.03) higher pain burden (13.0 vs. 9.8; t=3.09, P=0.002), higher acute functional disability (22.1 vs. 16.5; t=2.43, P=0.016), higher chronic functional disability (30.4 vs. 22.2; t=2.31, P=0.02), lower positive affect (22.9 vs. 27.6; t=2.23, P=0.027), and lower quality of life (56.2 vs. 62.9; t=1.99, P=0.049) than those youth with SCD without WSP. DISCUSSION: Assessment of WSP may identify a unique clinical phenotype of youth with SCD with differing treatment needs.
Authors: Steven K Reader; Laura M Rockman; Katherine M Okonak; Nicole M Ruppe; Colleen N Keeler; Anne E Kazak Journal: J Clin Psychol Med Settings Date: 2020-06
Authors: H Henry Lai; Thomas Jemielita; Siobhan Sutcliffe; Catherine S Bradley; Bruce Naliboff; David A Williams; Robert W Gereau; Karl Kreder; J Quentin Clemens; Larissa V Rodriguez; John N Krieger; John T Farrar; Nancy Robinson; J Richard Landis Journal: J Urol Date: 2017-03-31 Impact factor: 7.450