J Matías-Guíu1, C Oreja-Guevara2, J A Matias-Guiu2, U Gomez-Pinedo2. 1. Servicio de Neurología, Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense, IdiSSC, Madrid, España. Electronic address: matiasguiu@gmail.com. 2. Servicio de Neurología, Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense, IdiSSC, Madrid, España.
Abstract
INTRODUCTION: Several studies have found an association between multiple sclerosis and vitamin D (VD) deficiency, which suggests that VD may play a role in the immune response. However, few studies have addressed its role in remyelination. DEVELOPMENT: The VD receptor and the enzymes transforming VD into metabolites which activate the VD receptor are expressed in central nervous system (CNS) cells, which suggests a potential effect of VD on the CNS. Both in vitro and animal model studies have shown that VD may play a role in myelination by acting on factors that influence the microenvironment which promotes both proliferation and differentiation of neural stem cells into oligodendrocyte progenitor cells and oligodendrocytes. It remains unknown whether the mechanisms of internalisation of VD in the CNS are synergistic with or antagonistic to the mechanisms that facilitate the entry of VD metabolites into immune cells. CONCLUSIONS: VD seems to play a role in the CNS and our hypothesis is that VD is involved in remyelination. Understanding the basic mechanisms of VD in myelination is necessary to manage multiple sclerosis patients with VD deficiency.
INTRODUCTION: Several studies have found an association between multiple sclerosis and vitamin D (VD) deficiency, which suggests that VD may play a role in the immune response. However, few studies have addressed its role in remyelination. DEVELOPMENT: The VD receptor and the enzymes transforming VD into metabolites which activate the VD receptor are expressed in central nervous system (CNS) cells, which suggests a potential effect of VD on the CNS. Both in vitro and animal model studies have shown that VD may play a role in myelination by acting on factors that influence the microenvironment which promotes both proliferation and differentiation of neural stem cells into oligodendrocyte progenitor cells and oligodendrocytes. It remains unknown whether the mechanisms of internalisation of VD in the CNS are synergistic with or antagonistic to the mechanisms that facilitate the entry of VD metabolites into immune cells. CONCLUSIONS: VD seems to play a role in the CNS and our hypothesis is that VD is involved in remyelination. Understanding the basic mechanisms of VD in myelination is necessary to manage multiple sclerosispatients with VD deficiency.
Authors: A Martinez-Hernandez; E E Perez-Guerrero; M A Macias-Islas; C A Nava-Valdivia; A Villagomez-Vega; B Contreras-Haro; Y E Garcia-Ortega; Y Esparza-Guerrero; S G Gallardo-Moya; J I Gamez-Nava; L Gonzalez-Lopez; E Oliva-Flores; N A Rodriguez-Jimenez; F Cortes-Enriquez; A M Saldaña-Cruz Journal: J Immunol Res Date: 2021-12-23 Impact factor: 4.818