| Literature DB >> 273209 |
N Nagaratnam, A D Chetiyawardana, S Rajiyah.
Abstract
Three patients with aplastic anaemia following chloroquine therapy are described. In two, chloroquine had been administered in large doses over a long period. One of them subsequently developed acute myeloblastic leukaemia. The third received only a small dose and pancytopenia with aplasia followed three weeks after ingestion of the drug. The mechanism(s) of chloroquine-induced marrow injury is not known. A parallel to chloramphenicol-induced blood dyscrasias is drawn, but remains unproved.Entities:
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Year: 1978 PMID: 273209 PMCID: PMC2425073 DOI: 10.1136/pgmj.54.628.108
Source DB: PubMed Journal: Postgrad Med J ISSN: 0032-5473 Impact factor: 2.401