OBJECTIVES: The impact of TREM-1-mediated inflammation was investigated in different inflammatory settings. METHODS: Secondary analyses of an observational clinical pilot study, including 60 patients with septic shock, 30 postoperative controls and 30 healthy volunteers. RESULTS: Plasma levels of sTREM-1 were found to identify patients with septic shock more effectively than procalcitonin and C-reactive protein. Moreover, sTREM-1 was identified to be an early predictor for survival in patients with septic shock. CONCLUSION: Due to its diagnostic as well as prognostic value in sepsis syndrome, implementation of sTREM-1 measurements in routine diagnostics should be taken into account.
OBJECTIVES: The impact of TREM-1-mediated inflammation was investigated in different inflammatory settings. METHODS: Secondary analyses of an observational clinical pilot study, including 60 patients with septic shock, 30 postoperative controls and 30 healthy volunteers. RESULTS: Plasma levels of sTREM-1 were found to identify patients with septic shock more effectively than procalcitonin and C-reactive protein. Moreover, sTREM-1 was identified to be an early predictor for survival in patients with septic shock. CONCLUSION: Due to its diagnostic as well as prognostic value in sepsis syndrome, implementation of sTREM-1 measurements in routine diagnostics should be taken into account.
Entities:
Keywords:
(soluble) triggering receptor expressed on myeloid cells; Diagnosis; prognosis; sepsis; septic shock; severe sepsis
Authors: Bruno Francois; Simon Lambden; Sebastien Gibot; Marc Derive; Aurelie Olivier; Valerie Cuvier; Stephan Witte; Jean-Marie Grouin; Jean Jacques Garaud; Margarita Salcedo-Magguilli; Mitchell Levy; Pierre-François Laterre Journal: BMJ Open Date: 2021-07-07 Impact factor: 2.692