Sudeh Izadmehr1,2, Michael Leapman1,2, Adele R Hobbs1,2,3,4, Maria Katsigeorgis4, Fatima Nabizada-Pace1,2, Seyed Behzad Jazayeri4, David B Samadi5. 1. Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2. University of California San Francisco School of Medicine, San Francisco, CA, USA. 3. Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. 4. Department of Urology, Hofstra Northwell School of Medicine, Lenox Hill Hospital, 485 Madison Avenue, 21 Floor, New York, NY, 10022, USA. 5. Department of Urology, Hofstra Northwell School of Medicine, Lenox Hill Hospital, 485 Madison Avenue, 21 Floor, New York, NY, 10022, USA. robotmd@yahoo.com.
Abstract
PURPOSE: The natural history and optimal management strategy for men with human immunodeficiency virus (HIV) and prostate cancer remain to be definitively characterized. This study was conducted to evaluate the clinical characteristics and outcomes of HIV-seropositive men treated with robotic-assisted radical laparoscopic prostatectomy for localized prostate cancer. METHODS: After Institutional Review Board approval, a prospective database of 2175 operative cases of clinically localized prostate adenocarcinoma was reviewed. Thirteen patients were identified as HIV-positive. Tumor characteristics, operative outcomes, postoperative outcomes, histology (Gleason score), local invasion, biochemical recurrence, and surgical complications were compared with HIV-negative patients. RESULTS: There were no preoperative demographic differences between the HIV-positive and HIV-negative patients. HIV-positive patients had higher prostate specific antigen (PSA) levels at time of diagnosis which was not statistically significant. However, HIV-positive patients had higher D'Amico risk assessment (p < 0.05). There was no postoperative complication. HIV-positive patients treated with robotic prostatectomy had similarly favorable perioperative and short-term biochemical recurrence-free survival outcomes. CONCLUSION: Our findings show that minimally invasive prostatectomy can be safely considered as a therapeutic option in otherwise eligible HIV-positive patients with clinically significant prostate cancer. Further research is necessary to outline a diagnostic and treatment guideline for HIV-positive men in detection and treatment of prostate cancer.
PURPOSE: The natural history and optimal management strategy for men with human immunodeficiency virus (HIV) and prostate cancer remain to be definitively characterized. This study was conducted to evaluate the clinical characteristics and outcomes of HIV-seropositivemen treated with robotic-assisted radical laparoscopic prostatectomy for localized prostate cancer. METHODS: After Institutional Review Board approval, a prospective database of 2175 operative cases of clinically localized prostate adenocarcinoma was reviewed. Thirteen patients were identified as HIV-positive. Tumor characteristics, operative outcomes, postoperative outcomes, histology (Gleason score), local invasion, biochemical recurrence, and surgical complications were compared with HIV-negative patients. RESULTS: There were no preoperative demographic differences between the HIV-positive and HIV-negative patients. HIV-positive patients had higher prostate specific antigen (PSA) levels at time of diagnosis which was not statistically significant. However, HIV-positive patients had higher D'Amico risk assessment (p < 0.05). There was no postoperative complication. HIV-positive patients treated with robotic prostatectomy had similarly favorable perioperative and short-term biochemical recurrence-free survival outcomes. CONCLUSION: Our findings show that minimally invasive prostatectomy can be safely considered as a therapeutic option in otherwise eligible HIV-positive patients with clinically significant prostate cancer. Further research is necessary to outline a diagnostic and treatment guideline for HIV-positive men in detection and treatment of prostate cancer.
Authors: J L Silberstein; J K Parsons; K Palazzi-Churas; T M Downs; K Sakamoto; I H Derweesh; J Woldrich; C J Kane Journal: Prostate Cancer Prostatic Dis Date: 2010-09-28 Impact factor: 5.554
Authors: Adam B Murphy; Ramona Bhatia; Iman K Martin; David A Klein; Courtney M P Hollowell; Yaw Nyame; Elodi Dielubanza; Chad Achenbach; Rick A Kittles Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-07-25 Impact factor: 4.254
Authors: Tracy Ng; Nicholas F Stein; Jed Kaminetsky; Steven Berman; Hillel Y Marans; Bill McDermott; Anthony M Berson Journal: Urology Date: 2008-04-14 Impact factor: 2.649