| Literature DB >> 27318679 |
Kerstin Borgmann1, Sabrina Köcher1, Malte Kriegs1, Wael Yassin Mansour1, Ann Christin Parplys1, Thorsten Rieckmann1,2, Kai Rothkamm3.
Abstract
Cellular chromosomal DNA is the principal target through which ionising radiation exerts it diverse biological effects. This chapter summarises the relevant DNA damage signalling and repair pathways used by normal and tumour cells in response to irradiation. Strategies for tumour radiosensitisation are reviewed which exploit tumour-specific DNA repair deficiencies or signalling pathway addictions, with a special focus on growth factor signalling, PARP, cancer stem cells, cell cycle checkpoints and DNA replication. This chapter concludes with a discussion of DNA repair-related candidate biomarkers of tumour response which are of crucial importance for implementing precision medicine in radiation oncology.Entities:
Keywords: Biomarkers; DNA damage response; DNA double-strand break repair; DNA strand breaks; Ionising radiation; Molecular targeting
Mesh：
Year: 2016 PMID： 27318679 DOI： 10.1007/978-3-662-49651-0_1
Source DB: PubMed Journal: Recent Results Cancer Res ISSN： 0080-0015