Tammy Z Movsas1, Alan R Spitzer2, Ira H Gewolb3. 1. Zietchick Research Institute, Plymouth, Michigan and Midland County Department of Public Health, Midland, Michigan. Electronic address: tmovsas@gmail.com. 2. MEDNAX Services-Pediatrix Medical Group, Sunrise, Florida. 3. Department of Pediatrics & Human Development, Michigan State University, East Lansing, Michigan.
Abstract
PURPOSE: To investigate the association between postnatal steroids and retinopathy of prematurity (ROP) in neonates born with birth weights at the limit of viability (<500 g). METHODS: Data from the Pediatrix BabySteps Clinical Warehouse were retrospectively reviewed. The study population consisted of 1,472 neonates with birth weights of <500 g who were discharged alive from 167 NICUs between 1996 and 2013. Statistical significance for unadjusted comparisons between groups was determined using the χ(2) or t test. Logistic regression was used to calculate odds of ROP. RESULTS: In multivariate analysis, the odds of any ROP for steroid treated infants was 1.6 (95% CI, 1.2-2.2) compared to nontreated infants; the odds of advanced ROP was 1.7 (95% CI, 1.3-2.3). CONCLUSIONS: In our large study cohort of critically low birth weight infants ROP was more common in neonates exposed to postnatal steroids.
PURPOSE: To investigate the association between postnatal steroids and retinopathy of prematurity (ROP) in neonates born with birth weights at the limit of viability (<500 g). METHODS: Data from the Pediatrix BabySteps Clinical Warehouse were retrospectively reviewed. The study population consisted of 1,472 neonates with birth weights of <500 g who were discharged alive from 167 NICUs between 1996 and 2013. Statistical significance for unadjusted comparisons between groups was determined using the χ(2) or t test. Logistic regression was used to calculate odds of ROP. RESULTS: In multivariate analysis, the odds of any ROP for steroid treated infants was 1.6 (95% CI, 1.2-2.2) compared to nontreated infants; the odds of advanced ROP was 1.7 (95% CI, 1.3-2.3). CONCLUSIONS: In our large study cohort of critically low birth weight infants ROP was more common in neonates exposed to postnatal steroids.
Authors: Sang Jin Kim; Alexander D Port; Ryan Swan; J Peter Campbell; R V Paul Chan; Michael F Chiang Journal: Surv Ophthalmol Date: 2018-04-19 Impact factor: 6.048
Authors: Kristbjörg Sveinsdóttir; David Ley; Holger Hövel; Vineta Fellman; Petra S Hüppi; Lois E H Smith; Ann Hellström; Ingrid Hansen Pupp Journal: Neonatology Date: 2018-04-12 Impact factor: 4.035