Literature DB >> 27317800

S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis.

Anna Cantalupo1, Annarita Di Lorenzo2.   

Abstract

Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids are now recognized as important bioactive signaling molecules that modulate a variety of cellular functions, including those relevant to cancer and immunologic, inflammatory, and cardiovascular disorders. In this review, we discuss recent advances in our understanding of the role of sphingosine-1-phosphate (S1P) receptors in the regulation of vascular function, and focus on how de novo biosynthesized sphingolipids play a role in blood pressure homeostasis. The therapeutic potential of new drugs that target S1P signaling is also discussed.
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

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Year:  2016        PMID： 27317800      PMCID： PMC4959106          DOI： 10.1124/jpet.116.233205

Source DB:  PubMed          Journal:  J Pharmacol Exp Ther        ISSN： 0022-3565            Impact factor:   4.030


  119 in total

1.  Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.

Authors:  Suzanne Mandala; Richard Hajdu; James Bergstrom; Elizabeth Quackenbush; Jenny Xie; James Milligan; Rosemary Thornton; Gan-Ju Shei; Deborah Card; CarolAnn Keohane; Mark Rosenbach; Jeffrey Hale; Christopher L Lynch; Kathleen Rupprecht; William Parsons; Hugh Rosen
Journal:  Science       Date:  2002-03-28       Impact factor: 47.728

Review 2.  Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.

Authors:  Jason G Cyster; Susan R Schwab
Journal:  Annu Rev Immunol       Date:  2011-12-05       Impact factor: 28.527

3.  Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies?

Authors:  Elias Q Scherer; Darcy Lidington; Elmar Oestreicher; Wolfgang Arnold; Ulrich Pohl; Steffen-Sebastian Bolz
Journal:  Cardiovasc Res       Date:  2006-03-13       Impact factor: 10.787

4.  Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice.

Authors:  Mohammad Reza Hojjati; Zhiqiang Li; Xian-Cheng Jiang
Journal:  Biochim Biophys Acta       Date:  2005-08-24

5.  Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.

Authors:  Bongnam Jung; Hideru Obinata; Sylvain Galvani; Karen Mendelson; Bi-sen Ding; Athanasia Skoura; Bernd Kinzel; Volker Brinkmann; Shahin Rafii; Todd Evans; Timothy Hla
Journal:  Dev Cell       Date:  2012-09-11       Impact factor: 12.270

6.  Modulation of human arterial tone during pregnancy: the effect of the bioactive metabolite sphingosine-1-phosphate.

Authors:  Nicola K Hudson; Maureen O'Hara; Helen A Lacey; Jemma Corcoran; Denise G Hemmings; Mark Wareing; Philip Baker; Michael J Taggart
Journal:  Biol Reprod       Date:  2007-04-04       Impact factor: 4.285

7.  Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteries.

Authors:  Salvatore Salomone; Guray Soydan; Peter Ching-Tze Ip; Kristen M Park Hopson; Christian Waeber
Journal:  Pharmacol Res       Date:  2010-09-17       Impact factor: 7.658

8.  Deafness and stria vascularis defects in S1P2 receptor-null mice.

Authors:  Mari Kono; Inna A Belyantseva; Athanasia Skoura; Gregory I Frolenkov; Matthew F Starost; Jennifer L Dreier; Darcy Lidington; Steffen-Sebastian Bolz; Thomas B Friedman; Timothy Hla; Richard L Proia
Journal:  J Biol Chem       Date:  2007-02-06       Impact factor: 5.157

Review 9.  FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.

Authors:  Volker Brinkmann
Journal:  Br J Pharmacol       Date:  2009-10-08       Impact factor: 8.739

10.  Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice.

Authors:  Tae-Sik Park; Robert L Panek; Sandra Bak Mueller; Jeffrey C Hanselman; Wendy S Rosebury; Andrew W Robertson; Erick K Kindt; Reynold Homan; Sotirios K Karathanasis; Mark D Rekhter
Journal:  Circulation       Date:  2004-11-15       Impact factor: 29.690
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  15 in total

1.  Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats.

Authors:  Hazel Huang; Ali Aminian; Monique Hassan; Olivia Dan; Christopher L Axelrod; Philip R Schauer; Stacy A Brethauer; John P Kirwan
Journal:  Obes Surg       Date:  2019-07       Impact factor: 4.129

2.  L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway.

Authors:  Emma Mitidieri; Danila Gurgone; Elisabetta Caiazzo; Teresa Tramontano; Carla Cicala; Raffaella Sorrentino; Roberta d'Emmanuele di Villa Bianca
Journal:  Br J Pharmacol       Date:  2019-04-22       Impact factor: 8.739

3.  An engineered S1P chaperone attenuates hypertension and ischemic injury.

Authors:  Steven L Swendeman; Yuquan Xiong; Anna Cantalupo; Hui Yuan; Nathalie Burg; Yu Hisano; Andreane Cartier; Catherine H Liu; Eric Engelbrecht; Victoria Blaho; Yi Zhang; Keisuke Yanagida; Sylvain Galvani; Hideru Obinata; Jane E Salmon; Teresa Sanchez; Annarita Di Lorenzo; Timothy Hla
Journal:  Sci Signal       Date:  2017-08-15       Impact factor: 8.192

4.  S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure.

Authors:  Anna Cantalupo; Antonella Gargiulo; Elona Dautaj; Catherine Liu; Yi Zhang; Timothy Hla; Annarita Di Lorenzo
Journal:  Hypertension       Date:  2017-06-12       Impact factor: 10.190

5.  S1P (Sphingosine-1-Phosphate)-Induced Vasodilation in Human Resistance Arterioles During Health and Disease.

Authors:  Boran Katunaric; Gopika SenthilKumar; Mary E Schulz; Nilto De Oliveira; Julie K Freed
Journal:  Hypertension       Date:  2022-08-22       Impact factor: 9.897

6.  Sphingolipid Signature of Human Feto-Placental Vasculature in Preeclampsia.

Authors:  Ilaria Del Gaudio; Linda Sasset; Annarita Di Lorenzo; Christian Wadsack
Journal:  Int J Mol Sci       Date:  2020-02-04       Impact factor: 5.923

Review 7.  Sphingosine 1-Phosphate in Malaria Pathogenesis and Its Implication in Therapeutic Opportunities.

Authors:  Gunanidhi Dhangadamajhi; Shailja Singh
Journal:  Front Cell Infect Microbiol       Date:  2020-08-14       Impact factor: 5.293

8.  Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.

Authors:  Maria E Falzone; Jan Rheinberger; Byoung-Cheol Lee; Thasin Peyear; Linda Sasset; Ashleigh M Raczkowski; Edward T Eng; Annarita Di Lorenzo; Olaf S Andersen; Crina M Nimigean; Alessio Accardi
Journal:  Elife       Date:  2019-01-16       Impact factor: 8.140

9.  Cardiovascular Effects of Pharmacological Targeting of Sphingosine Kinase 1.

Authors:  Ewelina Józefczuk; Ryszard Nosalski; Blessy Saju; Eva Crespo; Piotr Szczepaniak; Tomasz Jan Guzik; Mateusz Siedlinski
Journal:  Hypertension       Date:  2019-12-16       Impact factor: 10.190

Review 10.  Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19.

Authors:  Eileen M McGowan; Nahal Haddadi; Najah T Nassif; Yiguang Lin
Journal:  Int J Mol Sci       Date:  2020-09-29       Impact factor: 5.923
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