Literature DB >> 2731751

Effects of gastrointestinal hormones on the growth of human intestinal epithelial cells in vitro.

C Simopoulos1, J D Gaffen, A Bennett.   

Abstract

The growth of cultured epithelium like cells from human normal embryonic intestine was studied in response to various hormones using a method that quantifies the number of cells by the amount of dye that they bind after fixation. Gastrin and neurotensin in the pg/ml range and higher caused small increases in cell growth. Glucagon and VIP were stimulatory in the low ng/ml range, whereas somatostatin and bombesin had no effect at the lower concentrations but were stimulatory at the highest concentration tested (10 and 100 ng/ml respectively). Secretin and pancreozymin (cholecystokinin) seemed to be ineffective.

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Year:  1989        PMID： 2731751      PMCID： PMC1434197          DOI： 10.1136/gut.30.5.600

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  23 in total

1.  Quantitation of dye binding by cell monolayers in a microtiter system.

Authors:  M R Barer; H Lyon; B S Drasar
Journal:  Histochem J       Date:  1986 Feb-Mar

Review 2.  The role of regulatory peptides in postnatal metabolic adaptation.

Authors:  A Aynsley-Green
Journal:  Acta Endocrinol Suppl (Copenh)       Date:  1986

Review 3.  Gut glucagon, enteroglucagon, gut glucagonlike immunoreactivity, glicentin--current status.

Authors:  J J Holst
Journal:  Gastroenterology       Date:  1983-06       Impact factor: 22.682

4.  Effects of gastrin, glutamine, and somatostatin on the in vitro growth of normal and malignant human gastric mucosal cells.

Authors:  M P Moyer; A Armstrong; J B Aust; B A Levine; K R Sirinek
Journal:  Arch Surg       Date:  1986-03

5.  Plasma enteroglucagon and CCK levels and cell proliferation in defunctioned small bowel in the rat.

Authors:  G E Gornacz; M A Ghatei; M Y Al-Mukhtar; J C Yeats; T E Adrian; N A Wright; S R Bloom
Journal:  Dig Dis Sci       Date:  1984-11       Impact factor: 3.199

6.  Metabolic and endocrine consequences of depriving preterm infants of enteral nutrition.

Authors:  A Lucas; S R Bloom; A Aynsley-Green
Journal:  Acta Paediatr Scand       Date:  1983-03

7.  Stimulating effect of bombesin on the growth of gastrointestinal tract and pancreas in suckling rats.

Authors:  T Lehy; F Puccio; J Chariot; D Labeille
Journal:  Gastroenterology       Date:  1986-06       Impact factor: 22.682

8.  Effect of pentagastrin, secretin and cholecystokinin on growth and differentiation in organ cultured rabbit small intestine.

Authors:  E F Stange; A Schneider; E Seiffer; H Ditschuneit
Journal:  Horm Metab Res       Date:  1986-05       Impact factor: 2.936

9.  Pentagastrin stimulates in vitro growth of normal and malignant human colon epithelial cells.

Authors:  K R Sirinek; B A Levine; M P Moyer
Journal:  Am J Surg       Date:  1985-01       Impact factor: 2.565

10.  Glucagon enhances growth of cultured human colorectal cancer cells in vitro.

Authors:  M P Moyer; J B Aust; P S Dixon; B A Levine; K R Sirinek
Journal:  Am J Surg       Date:  1985-12       Impact factor: 2.565
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  4 in total

1.  Epithelial expression of vasoactive intestinal peptide in ulcerative colitis: down-regulation in markedly inflamed colon.

Authors:  Maria Jönsson; Orjan Norrgård; Sture Forsgren
Journal:  Dig Dis Sci       Date:  2011-12-06       Impact factor: 3.199

2.  Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice.

Authors:  Jing Li; Xian Li; Jun Song; Baoxiang Yan; Stephanie A Rock; Jianhang Jia; Jinpeng Liu; Chi Wang; Todd Weiss; Heidi L Weiss; Tianyan Gao; Ashfaqul Alam; B Mark Evers
Journal:  FASEB J       Date:  2020-05-02       Impact factor: 5.191

3.  Response of human intestinal epithelial cells to gastrointestinal hormones.

Authors:  R H Whitehead
Journal:  Gut       Date:  1989-12       Impact factor: 23.059

4.  Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and Hirschsprung's disease.

Authors:  V Lelievre; G Favrais; C Abad; H Adle-Biassette; Y Lu; P M Germano; G Cheung-Lau; J R Pisegna; P Gressens; G Lawson; J A Waschek
Journal:  Peptides       Date:  2007-05-18       Impact factor: 3.750
  4 in total

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