Zhe Xu1, Bo Jin2, Guangju Teng3, Yihui Rong4, Lijian Sun5, Jian Zhang6, Ning Du7, Liming Liu8, Haibin Su9, Yue Yuan10, Haoyang Chen11. 1. Treatment and Research Center for Infectious Diseases, 302 Hospital of PLA, Beijing, China. 2. Treatment and Research Center for Liver Cirrhosis, 302 Hospital of PLA, Beijing, China. 3. Treatment and Research Center for Non-Infectious Liver Diseases, 302 Hospital of PLA, Beijing, China. 4. Treatment and Research Center for Liver Tumor, 302 Hospital of PLA, Beijing, China. 5. Intensive Care Unit, 302 Hospital of PLA, Beijing, China. 6. Radiotherapy Center for Liver Tumor, 302 Hospital of PLA, Beijing, China. 7. Chinese and Western Medicine Combined for Liver Disease Diagnosis and Treatment Center, 302 Hospital of PLA, Beijing, China. 8. Center for Clinical Laboratory, 302 Hospital of PLA, Beijing, China. 9. Treatment and Research Center for Liver Failure, 302 Hospital of PLA, Beijing, China. 10. Department of Infection Control, 302 Hospital of PLA, Beijing, China. 11. Department of Medical Affairs, 302 Hospital of PLA, Beijing, China. Electronic address: chenhaoyang302@126.com.
Abstract
OBJECTIVE: We aimed to fully describe epidemiologic characteristics, clinical manifestations, and clinical outcomes of Ebola virus disease (EVD), as well as detect independent factors significantly associated with mortality of the disease. METHODS: One hundred thirty-nine confirmed EVD patients enrolled at the JUI Holding and Treatment Centre in western Sierra Leone between November 15, 2014, and January 18, 2015, and demographic and clinical data were retrospectively collected and analyzed. RESULTS: The median age of investigated patients was 29 years and 55.4% were women. Of them, 76 patients (54.7%) died and 63 patients (45.3%) were cured. Case fatality rate among male patients was higher than in female patients (69.4% vs 42.9%). Fatigue (82.0%), anorexia (70.5%), abdominal pain (59.7%), diarrhea (58.3%), vomiting (56.1%), fever (55.4%), and muscle pain (54.0%) were the most common symptoms. In addition, 55.4% of investigated patients reported fever. Bleeding was seen in 10.8% of patients. CONCLUSIONS: Our data show that mortality of EVD is associated with an older age, fever, and probably hiccups.
OBJECTIVE: We aimed to fully describe epidemiologic characteristics, clinical manifestations, and clinical outcomes of Ebola virus disease (EVD), as well as detect independent factors significantly associated with mortality of the disease. METHODS: One hundred thirty-nine confirmed EVD patients enrolled at the JUI Holding and Treatment Centre in western Sierra Leone between November 15, 2014, and January 18, 2015, and demographic and clinical data were retrospectively collected and analyzed. RESULTS: The median age of investigated patients was 29 years and 55.4% were women. Of them, 76 patients (54.7%) died and 63 patients (45.3%) were cured. Case fatality rate among male patients was higher than in female patients (69.4% vs 42.9%). Fatigue (82.0%), anorexia (70.5%), abdominal pain (59.7%), diarrhea (58.3%), vomiting (56.1%), fever (55.4%), and muscle pain (54.0%) were the most common symptoms. In addition, 55.4% of investigated patients reported fever. Bleeding was seen in 10.8% of patients. CONCLUSIONS: Our data show that mortality of EVD is associated with an older age, fever, and probably hiccups.
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