Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 CRISPR Outsourcing: Commissioning IHF for Site-Specific Integration of Foreign DNA at the CRISPR Array.

Literature DB >> 27315553

CRISPR Outsourcing: Commissioning IHF for Site-Specific Integration of Foreign DNA at the CRISPR Array.

Abstract

In this issue of Molecular Cell, Nuñez et al. (2016) report that site-specific integration of foreign DNA into CRISPR loci by the Cas1-Cas2 integrase complex is promoted by a host factor, IHF (integration host factor), that binds and bends CRISPR leader DNA.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2016 PMID： 27315553 PMCID： PMC5404415 DOI： 10.1016/j.molcel.2016.06.004

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

11 in total

Review 1. Bacterial nucleoid-associated proteins, nucleoid structure and gene expression.

Authors: Shane C Dillon; Charles J Dorman
Journal: Nat Rev Microbiol Date: 2010-02-08 Impact factor: 60.633

2. Crystal structure of an IHF-DNA complex: a protein-induced DNA U-turn.

Authors: P A Rice; S Yang; K Mizuuchi; H A Nash
Journal: Cell Date: 1996-12-27 Impact factor: 41.582

3. CRISPR Immunological Memory Requires a Host Factor for Specificity.

Authors: James K Nuñez; Lawrence Bai; Lucas B Harrington; Tracey L Hinder; Jennifer A Doudna
Journal: Mol Cell Date: 2016-05-19 Impact factor: 17.970

Review 4. Adaptation in CRISPR-Cas Systems.

Authors: Samuel H Sternberg; Hagen Richter; Emmanuelle Charpentier; Udi Qimron
Journal: Mol Cell Date: 2016-03-03 Impact factor: 17.970

Review 5. An updated evolutionary classification of CRISPR-Cas systems.

Authors: Kira S Makarova; Yuri I Wolf; Omer S Alkhnbashi; Fabrizio Costa; Shiraz A Shah; Sita J Saunders; Rodolphe Barrangou; Stan J J Brouns; Emmanuelle Charpentier; Daniel H Haft; Philippe Horvath; Sylvain Moineau; Francisco J M Mojica; Rebecca M Terns; Michael P Terns; Malcolm F White; Alexander F Yakunin; Roger A Garrett; John van der Oost; Rolf Backofen; Eugene V Koonin
Journal: Nat Rev Microbiol Date: 2015-09-28 Impact factor: 60.633

2. Asymmetric positioning of Cas1-2 complex and Integration Host Factor induced DNA bending guide the unidirectional homing of protospacer in CRISPR-Cas type I-E system.

Authors: K N R Yoganand; R Sivathanu; Siddharth Nimkar; B Anand
Journal: Nucleic Acids Res Date: 2016-11-29 Impact factor: 16.971

3. CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration.

Authors: Jon McGinn; Luciano A Marraffini
Journal: Mol Cell Date: 2016-09-08 Impact factor: 17.970

3 in total

CRISPR Outsourcing: Commissioning IHF for Site-Specific Integration of Foreign DNA at the CRISPR Array.

Review 1. Bacterial nucleoid-associated proteins, nucleoid structure and gene expression.

2. Crystal structure of an IHF-DNA complex: a protein-induced DNA U-turn.

3. CRISPR Immunological Memory Requires a Host Factor for Specificity.

Review 4. Adaptation in CRISPR-Cas Systems.

Review 5. An updated evolutionary classification of CRISPR-Cas systems.

6. Sequences spanning the leader-repeat junction mediate CRISPR adaptation to phage in Streptococcus thermophilus.

7. CRISPR adaptation biases explain preference for acquisition of foreign DNA.

8. Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.

9. Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity.

10. Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition.

1. Spermidine strongly increases the fidelity of Escherichia coli CRISPR Cas1-Cas2 integrase.

2. Asymmetric positioning of Cas1-2 complex and Integration Host Factor induced DNA bending guide the unidirectional homing of protospacer in CRISPR-Cas type I-E system.

3. CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration.