Xiaolin Hua1,2,3, Jiewen Zhang2,3,4, Yanfang Guo2,3, Minxue Shen2,3,5, Laura Gaudet2,3, Ghayath Janoudi6, Mark Walker2,3,7, Shi Wu Wen2,3,5,7. 1. a Department of Obstetrics , Xinhua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China. 2. b Department of Obstetrics and Gynecology, Faculty of Medicine , OMNI Research Group, University of Ottawa , Ottawa , Ontario , Canada. 3. c Clinical Epidemiology Program , Ottawa Hospital Research Institute , Ottawa , Ontario , Canada. 4. d Department of Obstetrics and Gynecology , Beijing Friendship Hospital, Capital Medical University , Beijing , China. 5. e School of Public Health , Central South University , Changsha , China. 6. f Canadian Agency for Drugs and Technologies in Health , Ottawa , Ontario , Canada. 7. g School of Epidemiology, Public Health, and Preventive Medicine , University of Ottawa Faculty of Medicine , Ottawa , Ontario , Canada.
Abstract
OBJECTIVE: To evaluate the effect of folic acid supplementation during pregnancy on the risk of gestational hypertension/preeclampsia. METHODS: A systematic review and meta-analysis were conducted. Medline, Embase, Scopus, and the Web of Science were searched from inception to December 2014. RESULTS: Out of 1224 potentially relevant studies, 13 studies met our inclusion criteria (2 randomized controlled trials (RCTs), 10 cohort studies, and 1 case-control study). The pooled relative risk (RR) and 95% confidence interval (CI) of the two RCTs were 0.62 (0.45-0.87) in the trial arm as compared with the placebo arm. The pooled RR was 0.92 (95% CI: 0.79-1.08) for nine cohort studies with available data on folic acid supplementation in pregnancy and gestational hypertension/preeclampsia. Pooled RR was 0.88 (95% CI: 0.76-1.02) for eight cohort studies with available data on folic acid supplementation and preeclampsia. CONCLUSION: Whether folic acid supplementation in pregnancy can prevent the occurrence of gestational hypertension/preeclampsia remains uncertain.
OBJECTIVE: To evaluate the effect of folic acid supplementation during pregnancy on the risk of gestational hypertension/preeclampsia. METHODS: A systematic review and meta-analysis were conducted. Medline, Embase, Scopus, and the Web of Science were searched from inception to December 2014. RESULTS: Out of 1224 potentially relevant studies, 13 studies met our inclusion criteria (2 randomized controlled trials (RCTs), 10 cohort studies, and 1 case-control study). The pooled relative risk (RR) and 95% confidence interval (CI) of the two RCTs were 0.62 (0.45-0.87) in the trial arm as compared with the placebo arm. The pooled RR was 0.92 (95% CI: 0.79-1.08) for nine cohort studies with available data on folic acid supplementation in pregnancy and gestational hypertension/preeclampsia. Pooled RR was 0.88 (95% CI: 0.76-1.02) for eight cohort studies with available data on folic acid supplementation and preeclampsia. CONCLUSION: Whether folic acid supplementation in pregnancy can prevent the occurrence of gestational hypertension/preeclampsia remains uncertain.
Authors: Mai-Lei Woo Kinshella; Shazmeen Omar; Kerri Scherbinsky; Marianne Vidler; Laura A Magee; Peter von Dadelszen; Sophie E Moore; Rajavel Elango Journal: Nutrients Date: 2021-01-30 Impact factor: 5.717
Authors: Shi Wu Wen; Ruth Rennicks White; Natalie Rybak; Laura M Gaudet; Stephen Robson; William Hague; Donnette Simms-Stewart; Guillermo Carroli; Graeme Smith; William D Fraser; George Wells; Sandra T Davidge; John Kingdom; Doug Coyle; Dean Fergusson; Daniel J Corsi; Josee Champagne; Elham Sabri; Tim Ramsay; Ben Willem J Mol; Martijn A Oudijk; Mark C Walker Journal: BMJ Date: 2018-09-12