| Literature DB >> 2731487 |
Y Ohmae1, H Yano, S Umezawa, T Tanaka, I Hibi, C Miyamoto, Y Furuichi.
Abstract
We investigated the bioactivities of the recombinant DNA-derived methionyl 20K hGH (20K-Met-hGH) and methionyl hGH (22K-Met-hGH). The growth-promoting activities in Nb2 cells of 20K-Met-hGH and 22K-Met-hGH were 10.7% and 93.5% of pituitary hGH (P-hGH), respectively. In the IM-9 lymphocyte assay, the binding activities of 20K-Met-hGH and 22K-Met-hGH to hGH receptor were 29.0% and 87.1% of P-hGH, respectively. Our data demonstrate that 20K-Met-hGH may have weaker biological potency than P-hGH.Mesh：
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Year: 1989 PMID： 2731487 DOI： 10.1507/endocrj1954.36.9
Source DB: PubMed Journal: Endocrinol Jpn ISSN： 0013-7219