Akash P Kansagra1, Marc C Mabray2, Donna M Ferriero3, A James Barkovich4, Duan Xu2, Christopher P Hess2. 1. Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., Campus Box 8131, Saint Louis, MO 63110. Electronic address: apkansagra@gmail.com. 2. Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-391, San Francisco, CA 94143. 3. Departments of Pediatrics and Neurology, University of California, San Francisco, 400 Parnassus Avenue, San Francisco, CA 94143. 4. Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-391, San Francisco, CA 94143; Departments of Pediatrics and Neurology, University of California, San Francisco, 400 Parnassus Avenue, San Francisco, CA 94143.
Abstract
PURPOSE: This study aims to apply neurite orientation dispersion and density imaging (NODDI) to measure white matter microstructural features during early development. METHODS: NODDI parameters were measured in twelve newborns and thirteen 6-month infants, all with perinatal clinical encephalopathy. RESULTS: Between 0 and 6 months, there were significant differences in fractional anisotropy (FA) for all tracts; in neurite density for internal capsules, optic radiations, and splenium; and in orientation dispersion for anterior limb of internal capsule and optic radiations. There were no appreciable differences in NODDI parameters related to outcome. CONCLUSION: NODDI may allow more detailed characterization of microstructural maturation than FA.
PURPOSE: This study aims to apply neurite orientation dispersion and density imaging (NODDI) to measure white matter microstructural features during early development. METHODS: NODDI parameters were measured in twelve newborns and thirteen 6-month infants, all with perinatal clinical encephalopathy. RESULTS: Between 0 and 6 months, there were significant differences in fractional anisotropy (FA) for all tracts; in neurite density for internal capsules, optic radiations, and splenium; and in orientation dispersion for anterior limb of internal capsule and optic radiations. There were no appreciable differences in NODDI parameters related to outcome. CONCLUSION: NODDI may allow more detailed characterization of microstructural maturation than FA.
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